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How to get fromGreenville to Jeffersonvilleby plane, bus (Greyhound, Flixbus, Amtrak), car, taxi, or bus (Greyhound, Flixbus)

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There are 5 ways to get from Greenville to Jeffersonville by plane, bus (Greyhound, Flixbus, Amtrak), car, taxi, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF)plane plane GSP - SDF
    5h 46m
    $143–704

  2. Drive 376.6 mi

    cheapest
    1. Drive from Greenville to Jeffersonvillecar car 376.6 mi
    8h 3m
    $69–100

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    15h 4m
    $129–294

  4. Taxi to Asheville Regional Airport, fly

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Louisville International Airport (SDF)plane plane AVL - SDF
    6h 44m
    $220–670

  5. Bus via Brentwood

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Tornado Bus Co - Nashville to El Mercadito Grocery - Clarksville, INbus bus
    15h 14m
    $151–396

Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) flights

Calendar94Weekly Planes
Duration4h 23mAverage Duration
Ticket$104Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Jeffersonville.ExpandLaunch map view
  • Distance: 324.6 mi
  • Duration: 5h 46m

What companies run services between Greenville, SC, USA and Jeffersonville, IN, USA?

Southwest Airlines, Delta, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) hourly. Alternatively, you can take a vehicle from Greenville to Court @ Spring via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, Nashville, Louisville, KY, and Liberty @ Roy Wilkins in around 15h 4m.

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