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How to get fromGreenville to Key Westby plane, bus (Flixbus, Greyhound), bus, train, car, taxi, or bus (Greyhound)

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There are 7 ways to get from Greenville to Key West by plane, bus (Flixbus, Greyhound), bus, train, car, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    4h 18m
    $132–471

  2. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    25h 41m
    $184–415

  3. Bus, train

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the train from Charlotte Amtrak Station to Carytrain train
    3. Take the train from Cary to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    37h 18m
    $458–989

  4. Drive 863.3 mi

    1. Drive from Greenville to Key Westcar car 863.3 mi
    16h 16m
    $158–228

  5. Taxi to Asheville Regional Airport, fly

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    3h 14m
    $214–507

  6. Drive to Columbia, fly

    1. Drive from Greenville to Columbia-Airport-CAEcar car
    2. Fly from Columbia (CAE) to Key West International Airport (EYW)plane plane CAE - EYW
    5h 55m
    $170–790

  7. Bus via Pembroke Pines

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Hollywood Sheridan Trirail Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    30h 8m
    $187–421

Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) flights

Calendar47Weekly Planes
Duration5h 16mAverage Duration
Ticket$81Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Key West.ExpandLaunch map view
  • Distance: 730.5 mi
  • Duration: 4h 18m

What companies run services between Greenville, SC, USA and Key West, FL, USA?

Delta, American Airlines, and Breeze Airways fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Greenville to N Roosevelt & 3rd Street via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 25h 41m.

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