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How to get fromGreenville to La Crosseby plane, bus, train, car, taxi, bus (Greyhound, Flixbus), or bus (Flixbus)

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There are 7 ways to get from Greenville to La Crosse by plane, bus, train, car, taxi, bus (Greyhound, Flixbus), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to La Crosse (LSE)plane plane GSP - LSE
    5h 43m
    $160–621

  2. Bus, train

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    27h 24m
    $248–571

  3. Bus, train via Cary

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the train from Charlotte Amtrak Station to Carytrain train
    3. Take the train from Cary to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    39h 31m
    $523–1,161

  4. Drive 950.2 mi

    1. Drive from Greenville to La Crossecar car 950.2 mi
    17h 23m
    $174–251

  5. Taxi to Asheville Regional Airport, fly

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to La Crosse (LSE)plane plane AVL - LSE
    6h 18m
    $232–587

  6. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to La Crossebus bus
    28h 36m
    $226–482

  7. Bus via Bloomington

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Bloomingtonbus bus
    3. Take the bus from Bloomington to Chicago Bus Stationbus bus
    4. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    5. Take the bus from Madison to La Crossebus bus
    29h 46m
    $233–471

Greenville–Spartanburg International Airport (GSP) to La Crosse (LSE) flights

Calendar42Weekly Planes
Duration6h 41mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

Map of how to get from Greenville to La Crosse.ExpandLaunch map view
  • Distance: 806.8 mi
  • Duration: 5h 43m

What companies run services between Greenville, SC, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Greenville–Spartanburg International Airport (GSP) to La Crosse (LSE) every 4 hours. Alternatively, you can take a vehicle from Greenville to La Crosse via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, and Milwaukee in around 28h 36m.

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