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How to get fromGreenville to Lake Cityby plane, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

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There are 8 ways to get from Greenville to Lake City by plane, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Jacksonville, bus

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Jacksonville (JAX)plane plane GSP - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    6h 52m
    $441–668

  2. Drive 368.8 mi

    cheapest
    1. Drive from Greenville to Lake Citycar car 368.8 mi
    8h 14m
    $68–98

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the bus from Charlotte Bus Station to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    13h 46m
    $121–291

  4. Fly to Gainesville Regional Airport, bus

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Gainesville Regional Airport (GNV)plane plane GSP - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    8h 29m
    $121–494

  5. Fly to Valdosta, bus

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Valdosta (VLD)plane plane GSP - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    8h 32m
    $140–516

  6. Fly to Orlando Sanford, drive

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Orlando Sanford (SFB)plane plane GSP - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Lake Citycar car
    4h 49m
    $139–523

  7. Bus via Atlanta

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    14h 1m
    $119–278

  8. Bus via Atlanta #2

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Lake City Bus Stationbus bus
    14h 41m
    $118–286

Greenville–Spartanburg International Airport (GSP) to Jacksonville (JAX) flights

Calendar97Weekly Planes
Duration4h 14mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Lake City.ExpandLaunch map view
  • Distance: 397.3 mi
  • Duration: 6h 52m

What companies run services between Greenville, SC, USA and Lake City, FL, USA?

You can take a vehicle from Greenville to Lake City Bus Station via Taqueria Guadalajara - Greenville, Charlotte, Tryon St & Mellow Dr, Transit Center- Bay A, Transit Center- Bay E, 4th St & Graham St, Charlotte Bus Station, and Jacksonville in around 13h 46m.

Airlines
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