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How to get fromGreenville to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), car, or taxi

Find Transport to Louisville

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There are 4 ways to get from Greenville to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF)plane plane GSP - SDF
    4h 35m
    $137–651

  2. Drive 376.5 mi

    cheapest
    1. Drive from Greenville to Louisvillecar car 376.5 mi
    8h 2m
    $69–100

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    13h 49m
    $128–296

  4. Taxi to Asheville Regional Airport, fly

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Louisville International Airport (SDF)plane plane AVL - SDF
    5h 32m
    $219–647

Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) flights

Calendar94Weekly Planes
Duration4h 23mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Louisville.ExpandLaunch map view
  • Distance: 320 mi
  • Duration: 4h 35m

What companies run services between Greenville, SC, USA and Louisville, KY, USA?

Southwest Airlines, Delta, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) hourly. Alternatively, you can take a vehicle from Greenville to Louisville, KY via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, and Nashville in around 13h 49m.

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