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How to get fromGreenville to Mayo Clinicby plane, bus (Greyhound, Flixbus), bus, train, car, taxi, or bus (Flixbus)

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There are 7 ways to get from Greenville to Mayo Clinic by plane, bus (Greyhound, Flixbus), bus, train, car, taxi, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Rochester

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Rochester (RST)plane plane GSP - RST
    6h 17m
    $142–638

  2. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    31h 29m
    $238–511

  3. Bus, train

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    5. Take the bus from St. Paul to Rochesterbus bus
    44h 7m
    $586–1,291

  4. Drive 1,015.2 mi

    1. Drive from Greenville to Mayo Cliniccar car 1,015.2 mi
    18h 26m
    $186–268

  5. Taxi to Asheville Regional Airport, fly to Rochester

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Rochester (RST)plane plane AVL - RST
    8h 37m
    $219–624

  6. Taxi to Asheville Regional Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Minneapolis–Saint Paul International Airport (MSP)plane plane AVL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 23m
    $290–766

  7. Bus via Bloomington

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Bloomingtonbus bus
    3. Take the bus from Bloomington to Chicago Bus Stationbus bus
    4. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    5. Take the bus from Madison to Rochesterbus bus
    31h 54m
    $253–491

Greenville–Spartanburg International Airport (GSP) to Rochester (RST) flights

Calendar40Weekly Planes
Duration7h 15mAverage Duration
Ticket$106Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Mayo Clinic.ExpandLaunch map view
  • Distance: 852 mi
  • Duration: 6h 17m

What companies run services between Greenville, SC, USA and Mayo Clinic, MN, USA?

United Airlines, American Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Rochester (RST) every 4 hours. Alternatively, you can take a vehicle from Greenville to Mayo Clinic via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, Chicago Bus Station, W Jackson Blvd, after S Clinton St, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 31h 29m.

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