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How to get fromGreenville to Mechanicsburgby plane, bus (Greyhound, Flixbus), bus, train, or car

Find Transport to Mechanicsburg

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There are 6 ways to get from Greenville to Mechanicsburg by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Harrisburg International Airport (MDT)plane plane GSP - MDT
    5h 43m
    $118–492

  2. Drive 536.3 mi

    cheapest
    1. Drive from Greenville to Mechanicsburgcar car 536.3 mi
    10h 1m
    $98–142

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the bus from Charlotte Bus Station to Baltimore Downtown Bus Stationbus bus
    3. Take the bus from Baltimore Downtown Bus Station to Harrisburg Bus Stationbus bus
    17h 25m
    $134–318

  4. Bus, train

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the train from Charlotte Amtrak Station to Washington Union Stationtrain train
    3. Take the bus from Washington Union Station to Harrisburg Bus Stationbus bus
    17h 49m
    $185–448

  5. Fly to Philadelphia International Airport, train

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Philadelphia International Airport (PHL)plane plane GSP - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    6h 46m
    $175–723

  6. Bus, train via Lynchburg

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the train from Charlotte Amtrak Station to Lynchburgtrain train
    3. Take the bus from Lynchburg Amtrak Station to Washington Union Stationbus bus
    4. Take the bus from Washington Union Station to Harrisburg Bus Stationbus bus
    19h 9m
    $164–393

Greenville–Spartanburg International Airport (GSP) to Harrisburg International Airport (MDT) flights

Calendar107Weekly Planes
Duration5h 6mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Mechanicsburg.ExpandLaunch map view
  • Distance: 505.7 mi
  • Duration: 5h 43m

What companies run services between Greenville, SC, USA and Mechanicsburg, Cumberland County, PA, USA?

United Airlines, American Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Harrisburg International Airport (MDT) hourly. Alternatively, you can take a vehicle from Greenville to E Main St & Arch St WB via Taqueria Guadalajara - Greenville, Charlotte, Tryon St & Mellow Dr, Transit Center- Bay A, Transit Center- Bay E, 4th St & Graham St, Charlotte Bus Station, Baltimore Downtown Bus Station, Harrisburg Bus Station, and Market Square Transfer Center in around 17h 25m.

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