Rome2Rio

How to get fromGreenville to Port Saint Lucieby taxi, plane, car, bus (Flixbus), bus, or bus (Greyhound)

Find Transport to Port Saint Lucie

See all options

There are 9 ways to get from Greenville to Port Saint Lucie by taxi, plane, car, bus (Flixbus), bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Asheville Regional Airport, fly to Orlando Sanford, drive

    best
    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Orlando Sanford (SFB)plane plane AVL - SFB
    3. Drive from Orlando-Sanford-Airport-SFB to Port Saint Luciecar car
    5h 1m
    $217–549

  2. Drive 593.8 mi

    cheapest
    1. Drive from Greenville to Port Saint Luciecar car 593.8 mi
    11h 4m
    $109–157

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Port St Luciebus bus FlixBus N2401
    17h 30m
    $148–311

  4. Fly Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane GSP - FLL
    2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    5h 58m
    $211–893

  5. Fly Greenville–Spartanburg International Airport to Miami International Airport, bus

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane plane GSP - MIA
    2. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    6h 13m
    $159–574

  6. Taxi to Asheville Regional Airport, fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane AVL - FLL
    3. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    6h 43m
    $238–609

  7. Taxi to Asheville Regional Airport, fly to President Donald J. Trump International Airport, bus

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to President Donald J. Trump International Airport (PBI)plane plane AVL - PBI
    3. Take the bus from WPB ITC at BAY D to GATLIN BLVD at I-95 P/R LOTbus bus
    7h 15m
    $222–610

  8. Bus to Charlotte Douglas International Airport, fly to Vero Beach Municipal Airport, taxi

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Vero Beach Municipal Airport (VRB)plane plane CLT - VRB
    3. Take the taxi from Vero Beach Municipal Airport (VRB) to Port Saint Lucietaxi taxi
    7h 50m
    $244–824

  9. Bus via Fort Pierce

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Fort Piercebus bus Greyhound US0630
    21h 30m
    $144–335

Asheville Regional Airport (AVL) to Orlando Sanford (SFB) flights

Calendar11Weekly Planes
Duration1h 32mAverage Duration
Ticket$58Cheapest Price
See schedules

Questions & Answers

Map of how to get from Greenville to Port Saint Lucie.ExpandLaunch map view
  • Distance: 646.8 mi
  • Duration: 5h 1m

What companies run services between Greenville, SC, USA and Port Saint Lucie, FL, USA?

You can take a vehicle from Greenville to SW PSL Blvd & Cameo Blvd - East via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, and SW Gatlin Blvd & SW Brescia St in around 17h 30m.

Airlines
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers