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How to get fromGreenville to Wheelingby plane, bus, bus (Greyhound), train, or car

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There are 6 ways to get from Greenville to Wheeling by plane, bus, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Pittsburgh International Airport, bus

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Pittsburgh International Airport (PIT)plane plane GSP - PIT
    2. Take the bus from Pittsburgh Intermodal Station to Wheeling Bus Stopbus bus
    5h 35m
    $134–565

  2. Drive 495.3 mi

    cheapest
    1. Drive from Greenville to Wheelingcar car 495.3 mi
    9h 30m
    $91–131

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the bus from Charlotte Bus Station to Charleston, WVbus bus
    3. Take the bus from Charleston, WV to Cambridgebus bus
    4. Take the bus from Cambridge, OH to Wheeling Bus Stopbus bus
    15h 26m
    $100–218

  4. Bus, train

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the train from Charlotte Amtrak Station to Carytrain train
    3. Take the train from Cary to Pittsburgh Amtrak Stationtrain train
    4. Take the bus from Pittsburgh Intermodal Station to Wheeling Bus Stopbus bus
    25h 42m
    $279–583

  5. Fly to John Glenn Columbus International Airport, bus

    1. Fly from Greenville–Spartanburg International Airport (GSP) to John Glenn Columbus International Airport (CMH)plane plane GSP - CMH
    2. Take the bus from Columbus to Wheeling Bus Stopbus bus
    6h 18m
    $160–768

  6. Bus via Atlanta

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Columbusbus bus
    3. Take the bus from Columbus to Wheeling Bus Stopbus bus
    23h 51m
    $161–301

Greenville–Spartanburg International Airport (GSP) to Pittsburgh International Airport (PIT) flights

Calendar55Weekly Planes
Duration3h 36mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Wheeling.ExpandLaunch map view
  • Distance: 498.6 mi
  • Duration: 5h 35m

What companies run services between Greenville, SC, USA and Wheeling, WV, USA?

You can take a vehicle from Greenville to Wheeling Bus Stop via Taqueria Guadalajara - Greenville, Charlotte, Tryon St & Mellow Dr, Transit Center- Bay A, Transit Center- Bay E, 4th St & Graham St, Charlotte Bus Station, Charleston, WV, Cambridge, and Cambridge, OH in around 15h 26m.

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