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How to get fromGrenoble to Sienaby bus, train, train (Trenitalia), car, or plane

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There are 7 ways to get from Grenoble to Siena by bus, train, train (Trenitalia), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Grenoble to Turinbus bus 744 / ...
    2. Take the train from Torino Porta Susa to Firenze S.M.N.train train Fr
    3. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    9h 42m
    €74–168

  2. Bus

    cheapest
    1. Take the bus from Grenoble to Florence Villa Constanza Bus Stationbus bus 1501
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    10h 25m
    €56–89

  3. Train

    1. Take the train from Grenoble to Chambery Challes Les Eauxtrain train Ter
    2. Take the train from Chambery Challes Les Eaux to Milano Centraletrain train Fr
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    10h 1m
    €92–200

  4. Drive  662.3 km

    1. Drive from Grenoble to Sienacar car 662.3 km
    7h 20m
    €105–151

  5. Train, fly to Florence Peretola Airport

    1. Take the train from Grenoble to Lyon-Saint Exupery Tgvtrain train
    2. Fly from Lyon–Saint Exupéry Airport (LYS) to Florence Peretola Airport (FLR)plane plane LYS - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    7h 3m
    €81–285

  6. Train, bus

    1. Take the train from Grenoble to Chambery Challes Les Eauxtrain train Ter
    2. Take the bus from Chambery Central Bus Station to Florence Villa Constanza Bus Stationbus bus
    3. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    14h 26m
    €58–120

  7. Train, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Grenoble to Lyon-Saint Exupery Tgvtrain train
    2. Fly from Lyon–Saint Exupéry Airport (LYS) to Bologna Guglielmo Marconi Airport (BLQ)plane plane LYS - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    7h 55m
    €104–319

Grenoble to Siena by bus and train

Calendar76Weekly Services
Duration9h 42mAverage Duration
Ticket€74Cheapest Price
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Questions & Answers

Map of how to get from Grenoble to Siena.ExpandLaunch map view
  • Distance: 751.2 km
  • Duration: 9h 42m

What companies run services between Grenoble, France and Siena, Italy?

You can take a train from Grenoble to Siena via Chambery Challes Les Eaux, Milano Centrale, and Firenze S.M.N. in around 10h 1m. Alternatively, you can take a bus from Grenoble to Siena via Florence Villa Constanza Bus Station in around 10h 25m.

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