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How to get fromGuanajuato to St. Louisby bus, plane, bus (Greyhound), shuttle, train, car, or bus (Amtrak, Flixbus)

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There are 11 ways to get from Guanajuato to St. Louis by bus, plane, bus (Greyhound), shuttle, train, car, or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Del Bajío International Airport, fly

    best
    1. Take the bus from Guanajuato to Leónbus bus
    2. Fly from Del Bajío International Airport (BJX) to Lambert–St. Louis International Airport (STL)plane plane BJX - STL
    11h 21m
    $179–813

  2. Bus via Tulsa

    1. Take the bus from Guanajuato to Leónbus bus
    2. Take the bus from León to Zacatecasbus bus
    3. Take the bus from Zacatecas to Tulsabus bus
    4. Take the bus from Tulsa Bus Station to St Louis Bus Stationbus bus
    40h 48m
    $371–441

  3. Shuttle, bus, train

    1. Take a shuttle bus from Guanajuato to Aguascalientesshuttle bus
    2. Take the bus from Aguascalientes to San Antonio Stationbus bus
    3. Take the train from San Antonio Station to St. Louistrain train
    42h 11m
    $710–1,211

  4. Drive  1,597 mi

    1. Drive from Guanajuato to St. Louiscar car 1,597 mi
    27h 22m
    $352–508

  5. Shuttle to Lic. Jesús Terán Peredo International Airport, fly

    1. Take a shuttle bus from Guanajuato to Aguascalientesshuttle bus
    2. Fly from Lic. Jesús Terán Peredo International Airport (AGU) to Lambert–St. Louis International Airport (STL)plane plane AGU - STL
    10h 37m
    $266–1,248

  6. Bus to Querétaro Intercontinental Airport, fly

    1. Take the bus from Guanajuato to Terminal de Autobuses de Querétaro Acceso 1bus bus
    2. Fly from Querétaro Intercontinental Airport (QRO) to Lambert–St. Louis International Airport (STL)plane plane QRO - STL
    12h 30m
    $207–898

  7. Bus, bus to General Francisco Mujica International Airport, fly

    1. Take the bus from Guanajuato to Salamancabus bus
    2. Take the bus from Salamanca to Moreliabus bus
    3. Fly from General Francisco Mujica International Airport (MLM) to Lambert–St. Louis International Airport (STL)plane plane MLM - STL
    12h 54m
    $291–1,182

  8. Bus, bus to San Luis Potosí Airport, fly

    1. Take the bus from Guanajuato to Leónbus bus
    2. Take the bus from León to San Luis Potosíbus bus
    3. Fly from San Luis Potosí Airport (SLP) to Lambert–St. Louis International Airport (STL)plane plane SLP - STL
    13h 21m
    $228–954

  9. Bus

    1. Take the bus from Guanajuato to Terminal de Autobuses de Querétaro Acceso 1bus bus
    2. Take the bus from Santiago de Querétaro to Marathon Gas Station - Marionbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    44h 6m
    $318–425

  10. Bus, train

    1. Take the bus from Guanajuato to Celayabus bus
    2. Take the bus from Celaya to San Marcosbus bus
    3. Take the train from San Marcos Amtrak to St. Louistrain train
    45h 17m
    $637–1,024

  11. Bus, train via San Luis Potosí

    1. Take the bus from Guanajuato to Leónbus bus
    2. Take the bus from León to San Luis Potosíbus bus
    3. Take the bus from San Luis Potosí to San Marcosbus bus
    4. Take the train from San Marcos Amtrak to St. Louistrain train
    46h 10m
    $627–1,021

Del Bajío International Airport (BJX) to Lambert–St. Louis International Airport (STL) flights

Calendar44Weekly Planes
Duration6h 53mAverage Duration
Ticket$178Cheapest Price
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Comparing Your Travel Options

Map of how to get from Guanajuato to St. Louis.ExpandLaunch map view
  • Distance: 1,455.9 mi
  • Duration: 11h 21m

What companies run services between Guanajuato, Mexico and St. Louis, MO, USA?

You can take a bus from Guanajuato to St Louis Bus Station via León, Zacatecas, Tulsa, (7031) 21St St. & Garnett Rd. Eb, (6999) East Gate Sub Hub, (8299) Boston Ave & 4th St NB, and Tulsa Bus Station in around 40h 48m.

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