There are 5 ways to get from Guayaquil to Santiago by plane, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from José Joaquín De Olmedo International Airport (GYE) to Comodoro Arturo Merino Benítez International Airport (SCL)plane GYE - SCL
5h 13m$241–529Bus #2
cheapest- Take the bus from Terminal Terrestre de Guayaquil to Tumbesbus
- Take the bus from Tumbes to Gran Terminal Terrestre Plaza Nortebus
- Take the bus from Gran Terminal Terrestre Plaza Norte to Terminal Sur de Santiagobus
3d 10h$142–225Bus via Tumbes
- Take the bus from Terminal Terrestre de Guayaquil to Tumbesbus
- Take the bus from Tumbes to Gran Terminal Terrestre Plaza Nortebus
- Take the bus from Gran Terminal Terrestre Plaza Norte to Terminal San Borjabus
2d 19h$263–335Drive 4,689.6 km
- Drive from Guayaquil to Santiagocar 4,689.6 km
2d 12h$579–836Bus
- Take the bus from Terminal Terrestre de Guayaquil to Lima Javier Pradobus Lima / ...
- Take the bus from Lima Javier Prado to Terminal Sur de Santiagobus Lima
3d 7h$144–286
José Joaquín De Olmedo International Airport (GYE) to Comodoro Arturo Merino Benítez International Airport (SCL) flights
Questions & Answers
The cheapest way to get from Guayaquil to Santiago is to bus which costs $140 - $230 and takes 3 days 10h.
The fastest way to get from Guayaquil to Santiago is to fly which takes 5h 13m and costs $240 - $550.
No, there is no direct bus from Guayaquil to Santiago. However, there are services departing from Terminal Terrestre de Guayaquil and arriving at Terminal San Borja via Tumbes and Gran Terminal Terrestre Plaza Norte. The journey, including transfers, takes approximately 2 days 19h.
The distance between Guayaquil and Santiago is 3614 km. The road distance is 4689.6 km.
The best way to get from Guayaquil to Santiago without a car is to bus via Tumbes which takes 2 days 19h and costs $260 - $340.
It takes approximately 5h 13m to get from Guayaquil to Santiago, including transfers.
Guayaquil to Santiago bus services, operated by Cruz Del Sur International, depart from Terminal Terrestre de Guayaquil station.
The best way to get from Guayaquil to Santiago is to fly which takes 5h 13m and costs $240 - $550. Alternatively, you can bus via Tumbes, which costs $260 - $340 and takes 2 days 19h.
Guayaquil to Santiago bus services, operated by Cruz Del Sur International, arrive at Tumbes station.
Santiago is 1h ahead of Guayaquil. It is currently 9:56 PM in Guayaquil and 10:56 PM in Santiago.
What companies run services between Guayaquil, Ecuador and Santiago, Chile?
LATAM Chile and Avianca - Aerovías del Continente Americano S.A. fly from José Joaquín De Olmedo International Airport (GYE) to Comodoro Arturo Merino Benítez International Airport (SCL) every 4 hours. Alternatively, you can take a bus from Terminal Terrestre de Guayaquil to Terminal San Borja via Tumbes, Tumbes, and Gran Terminal Terrestre Plaza Norte in around 2d 19h.
- Website
- latam.com
Flights from José Joaquín De Olmedo International Airport to Comodoro Arturo Merino Benítez International Airport
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $230–550
Flights from José Joaquín De Olmedo International Airport to Comodoro Arturo Merino Benítez International Airport via Lima
- Ave. Duration
- 7h 13m
- When
- Every day
- Estimated price
- $230–550
- Website
- avianca.com
Flights from José Joaquín De Olmedo International Airport to Comodoro Arturo Merino Benítez International Airport via Bogota
- Ave. Duration
- 9h 20m
- When
- Every day
- Estimated price
- $260–550
- Phone
- +51 1 311-5050
- Website
- cruzdelsur.com.pe
Bus from Terminal Terrestre de Guayaquil to Tumbes
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $13–15
- Website
- https://www.cruzdelsur.com.pe/home-en/
Bus from Terminal Terrestre de Guayaquil to Lima Javier Prado
- Ave. Duration
- 24h
- Frequency
- Twice daily
- Estimated price
- $45–120
- Website
- https://www.cruzdelsur.com.pe/home-en/
Bus from Lima Javier Prado to Terminal Sur de Santiago
- Ave. Duration
- 2d 6h
- Frequency
- Once daily
- Estimated price
- $95–170
- Website
- https://www.cruzdelsur.com.pe/home-en/
Bus from Terminal Terrestre de Guayaquil to Tumbes
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $13–15
- Website
- https://www.cruzdelsur.com.pe/home-en/
Bus from Gran Terminal Terrestre Plaza Norte to Terminal Sur de Santiago
- Ave. Duration
- 2d 7h
- Frequency
- Once daily
- Estimated price
- $100–170
- Website
- https://www.cruzdelsur.com.pe/home-en/
- Phone
- +51 511 418 1111
- [email protected]
- Website
- civa.com.pe
Bus from Tumbes to Gran Terminal Terrestre Plaza Norte
- Ave. Duration
- 17h 10m
- Frequency
- Every 4 hours
- Estimated price
- $40–60
- Schedules at
- civa.com.pe
- Phone
- +51 9 6788 4526
- [email protected]
- Website
- facebook.com
Bus from Gran Terminal Terrestre Plaza Norte to Terminal San Borja
- Ave. Duration
- 45h 7m
- Frequency
- Once daily
- Estimated price
- $210–260
- Website
- https://www.facebook.com/lineasdelosandesve/
- Phone
- +51 994 656 518
- [email protected]
- Website
- oltursa.pe
Bus from Tumbes to Gran Terminal Terrestre Plaza Norte
- Ave. Duration
- 21h 45m
- Frequency
- 3 times a day
- Estimated price
- $29–40
- Website
- https://www.oltursa.pe/?lang=en
Want to know more about travelling around the world?
Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Want to know more about Flixbus?, How to get from Gatwick Airport into central London, and How do I buy a London Underground ticket? - to help you get the most out of your next trip.
More Questions & Answers
Yes, the driving distance between Guayaquil to Santiago is 4690 km. It takes approximately 2 days 12h to drive from Guayaquil to Santiago.
There are 3508+ hotels available in Santiago.









