There are 4 ways to get from Guayos to Santiago de Cuba by bus, train, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Sancti Spíritus to Santiago de Cubabus Sancti spiritus
7h 15m$15–22Train
cheapest- Take the train from Guayos to Santiago de Cubatrain 11 / ...
10h 34m$3–9Drive 526.5 km
- Drive from Guayos to Santiago de Cubacar 526.5 km
7h 54m$60–87Train, fly
- Take the train from Guayos to Santa Claratrain
- Fly from Abel Santamaría Airport (SNU) to Antonio Maceo International Airport (SCU)plane SNU - SCU
22h 46m$104–479
Abel Santamaría Airport (SNU) to Antonio Maceo International Airport (SCU) flights
Questions & Answers
The cheapest way to get from Guayos to Santiago de Cuba is to train which costs $3 - $9 and takes 10h 34m.
The fastest way to get from Guayos to Santiago de Cuba is to bus which takes 7h 15m and costs $15 - $22.
No, there is no direct bus from Guayos to Santiago de Cuba. However, there are services departing from Sancti Spíritus and arriving at Santiago de Cuba via . The journey, including transfers, takes approximately 7h 15m.
Yes, there is a direct train departing from Guayos and arriving at Santiago de Cuba. Services depart twice a week, and operate Monday. The journey takes approximately 10h 34m.
The distance between Guayos and Santiago de Cuba is 531 km. The road distance is 526.5 km.
The best way to get from Guayos to Santiago de Cuba without a car is to bus which takes 7h 15m and costs $15 - $22.
It takes approximately 7h 15m to get from Guayos to Santiago de Cuba, including transfers.
Guayos to Santiago de Cuba bus services, operated by Ómnibus Nacionales, depart from Sancti Spíritus station.
Guayos to Santiago de Cuba train services, operated by Ferrocarriles de Cuba, depart from Guayos station.
The best way to get from Guayos to Santiago de Cuba is to bus which takes 7h 15m and costs $15 - $22. Alternatively, you can train, which costs $3 - $9 and takes 10h 34m.
What companies run services between Guayos, Cuba and Santiago de Cuba?
Ómnibus Nacionales operates a bus from Sancti Spíritus to Santiago de Cuba 4 times a week. Tickets cost $3–7 and the journey takes 7h. Alternatively, Ferrocarriles de Cuba operates a train from Guayos to Santiago de Cuba twice a week. Tickets cost $3–9 and the journey takes 10h 34m.
- Website
- aa.com
Flights from Abel Santamaría Airport to Antonio Maceo International Airport via Miami
- Ave. Duration
- 19h 30m
- When
- Wednesday to Sunday
- Estimated price
- $90–460
- Phone
- +53 7 855 5025 / 7 855 5026 / 5 2161205
- [email protected]
- Website
- facebook.com
Train from Guayos to Santiago de Cuba
- Ave. Duration
- 10h 34m
- Frequency
- Twice a week
- Estimated price
- $3–9
- Schedules at
- https://thebusschedule.com/EN/cu/index.php
- Normal
- $3–4
- Climatizado
- $4–5
Train from Guayos to Santa Clara
- Ave. Duration
- 1h 16m
- Frequency
- Once daily
- Estimated price
- $1–2
- Schedules at
- https://thebusschedule.com/EN/cu/index.php
- Normal
- $1
- Climatizado
- $1
- Phone
- +53 7873 7373
- [email protected]
- Website
- eon.wetransp.com
Bus from Sancti Spíritus to Santiago de Cuba
- Ave. Duration
- 7h
- Frequency
- 4 times a week
- Estimated price
- $3–7
- Schedules at
- eon.wetransp.com
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More Questions & Answers
Guayos to Santiago de Cuba bus services, operated by Ómnibus Nacionales, arrive at Santiago de Cuba station.
Guayos to Santiago de Cuba train services, operated by Ferrocarriles de Cuba, arrive at Santiago de Cuba station.
Yes, the driving distance between Guayos to Santiago de Cuba is 527 km. It takes approximately 7h 54m to drive from Guayos to Santiago de Cuba.





