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How to get fromGuelph to Chicagoby train, plane, train (Amtrak), bus (Flixbus, Greyhound), car, shuttle, or bus (Flixbus, Amtrak)

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There are 9 ways to get from Guelph to Chicago by train, plane, train (Amtrak), bus (Flixbus, Greyhound), car, shuttle, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    6h 17m
    $382–1,117

  2. Bus

    cheapest
    1. Take the bus from Kitchener to Detroit Bus Stationbus bus FlixBus N2710
    2. Take the bus from Detroit Bus Station to Chicago Bus Stationbus bus Greyhound US0160
    14h 14m
    $74–134

  3. Train

    1. Take the train from Guelph to Sarniatrain train VIA Rail
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train Blue Water
    11h 14m
    $121–370

  4. Drive 468.6 mi

    1. Drive from Guelph to Chicagocar car 468.6 mi
    7h 55m
    $108–155

  5. Train to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    6h 18m
    $182–1,418

  6. Train, shuttle to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    7h 23m
    $262–447

  7. Train, shuttle to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    7h 51m
    $272–437

  8. Drive to Erie International Airport, fly to Chicago O'Hare International Airport

    1. Drive from Guelph to Erie-Airport-ERIcar car
    2. Fly from Erie International Airport (ERI) to Chicago O'Hare International Airport (ORD)plane plane ERI - ORD
    6h 33m
    $91–348

  9. Bus via Dearborn

    1. Take the bus from Kitchener to Detroit Bus Stationbus bus FlixBus N2710
    2. Take the bus from Dearborn to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    14h 33m
    $116–176

Guelph to Chicago by train and car

Calendar7Weekly Services
Duration11h 14mAverage Duration
Ticket$121Cheapest Price
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Questions & Answers

Map of how to get from Guelph to Chicago.ExpandLaunch map view
  • Distance: 493 mi
  • Duration: 6h 17m

What companies run services between Guelph, ON, Canada and Chicago, IL, USA?

You can take a train from Guelph to Chicago Union Station via Sarnia and Port Huron Station in around 11h 14m. Alternatively, you can take a bus from Guelph Central GO Bus to Chicago Bus Station via Victoria / Bingemans Centre Dr., Kitchener, and Detroit Bus Station in around 14h 14m.

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