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How to get fromGuelph to Des Moinesby train, plane, bus, bus (Flixbus, Greyhound), car, or shuttle

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There are 10 ways to get from Guelph to Des Moines by train, plane, bus, bus (Flixbus, Greyhound), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Toronto Pearson International Airport, fly

    best
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Des Moines (DSM)plane plane YYZ - DSM
    8h 1m
    $138–634

  2. Bus

    cheapest
    1. Take the bus from Kitchener to Detroit Bus Stationbus bus
    2. Take the bus from Detroit, MI to Indianapolis, INbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    24h 22m
    $134–274

  3. Train, bus

    1. Take the train from Guelph to Sarniatrain train
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    18h 53m
    $186–490

  4. Drive 783.4 mi

    1. Drive from Guelph to Des Moinescar car 783.4 mi
    13h 7m
    $180–259

  5. Train to Toronto Island Airport, fly

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Fly from Toronto Island Airport (YTZ) to Des Moines (DSM)plane plane YTZ - DSM
    7h 49m
    $147–684

  6. Train, shuttle to Buffalo Niagara International Airport, fly

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane plane BUF - DSM
    9h 5m
    $298–1,054

  7. Drive to Erie International Airport, fly

    1. Drive from Guelph to Erie-Airport-ERIcar car
    2. Fly from Erie International Airport (ERI) to Des Moines (DSM)plane plane ERI - DSM
    8h 15m
    $181–734

  8. Train, shuttle to Detroit, fly

    1. Take the train from Guelph to Londontrain train
    2. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    3. Fly from Detroit (DTW) to Des Moines (DSM)plane plane DTW - DSM
    10h 18m
    $202–976

  9. Train, bus via Galesburg

    1. Take the train from Guelph to Sarniatrain train
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    20h 45m
    $216–565

  10. Bus via Chicago

    1. Take the bus from Kitchener to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to South Havenbus bus
    3. Take the bus from South Haven to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    24h 27m
    $141–259

Guelph to Des Moines by train, car, foot, and bus

Calendar7Weekly Services
Duration18h 53mAverage Duration
Ticket$186Cheapest Price
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Questions & Answers

Map of how to get from Guelph to Des Moines.ExpandLaunch map view
  • Distance: 773.6 mi
  • Duration: 8h 1m

What companies run services between Guelph, ON, Canada and Des Moines, IA, USA?

You can take a bus from Guelph Central GO Bus to Des Moines via Victoria / Bingemans Centre Dr., Kitchener, Detroit, MI, and Indianapolis Union Station in around 24h 22m.

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