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How to get fromGuelph to Knoxvilleby train, plane, bus, car, or shuttle

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There are 11 ways to get from Guelph to Knoxville by train, plane, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Toronto Pearson International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS)plane plane YYZ - TYS
    7h 57m
    $176–683

  2. Drive 692.6 mi

    cheapest
    1. Drive from Guelph to Knoxvillecar car 692.6 mi
    11h 57m
    $159–229

  3. Train, bus

    1. Take the train from Guelph Central GO to Union Station GOtrain train Ki
    2. Take the bus from Toronto to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    25h 58m
    $273–406

  4. Train to Toronto Island Airport, fly to Mcghee Tyson Airport

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Fly from Toronto Island Airport (YTZ) to Mcghee Tyson Airport (TYS)plane plane YTZ - TYS
    8h 37m
    $205–783

  5. Train, shuttle to Buffalo Niagara International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    9h 10m
    $346–1,203

  6. Train to Toronto Pearson International Airport, fly to Nashville, drive

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Nashville (BNA)plane plane YYZ - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    8h 26m
    $181–1,363

  7. Train, shuttle to Detroit, fly to Mcghee Tyson Airport

    1. Take the train from Guelph to Londontrain train
    2. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    3. Fly from Detroit (DTW) to Mcghee Tyson Airport (TYS)plane plane DTW - TYS
    10h 6m
    $240–1,075

  8. Train to Toronto Pearson International Airport, fly to Covington, drive

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Covington (CVG)plane plane YYZ - CVG
    3. Drive from Covington (CVG) to Knoxvillecar car
    9h 20m
    $656–1,028

  9. Bus

    1. Take the bus from Guelph Central GO Bus to Winston Churchill Transitway Stationbus bus 29
    2. Take the bus from Mississauga to New Yorkbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    27h 3m
    $256–572

  10. Bus, train via Farragut

    1. Take the bus from Guelph Central GO Bus to Aldershot GO Busbus bus 17
    2. Take the train from Aldershot to New York Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    27h 50m
    $320–571

  11. Bus, train

    1. Take the bus from Guelph Central GO Bus to Aldershot GO Busbus bus 17
    2. Take the train from Aldershot to New York Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    27h 54m
    $275–481

Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS) flights

Calendar145Weekly Planes
Duration5h 30mAverage Duration
Ticket$118Cheapest Price
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Questions & Answers

Map of how to get from Guelph to Knoxville.ExpandLaunch map view
  • Distance: 643.3 mi
  • Duration: 7h 57m

What companies run services between Guelph, ON, Canada and Knoxville, TN, USA?

You can take a bus from Guelph Central GO Bus to Knoxville via Winston Churchill Transitway Station, Mississauga, New York, 42 St-Times Square, Canal St, New York, and Knoxville in around 27h 3m.

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