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How to get fromGuelph to Louisvilleby train, plane, bus, car, shuttle, bus (Flixbus, Greyhound), or bus (Flixbus, Amtrak)

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There are 13 ways to get from Guelph to Louisville by train, plane, bus, car, shuttle, bus (Flixbus, Greyhound), or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Toronto Pearson International Airport, fly to Louisville International Airport

    best
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Louisville International Airport (SDF)plane plane YYZ - SDF
    9h 5m
    $96–515

  2. Bus

    cheapest
    1. Take the bus from Kitchener to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Cincinnati Bus Stationbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    15h 59m
    $68–164

  3. Train, bus

    1. Take the train from Guelph to Londontrain train
    2. Take the train from London to Windsortrain train
    3. Take the bus from Detroit, MI to Indianapolis, INbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    15h 13m
    $99–444

  4. Train, bus via Chicago

    1. Take the train from Guelph to Sarniatrain train
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    20h 33m
    $193–535

  5. Drive  539.8 mi

    1. Drive from Guelph to Louisvillecar car 539.8 mi
    9h 24m
    $124–179

  6. Train to Toronto Island Airport, fly to Louisville International Airport

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Fly from Toronto Island Airport (YTZ) to Louisville International Airport (SDF)plane plane YTZ - SDF
    8h 59m
    $121–666

  7. Train, shuttle to Buffalo Niagara International Airport, fly to Louisville International Airport

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    9h 52m
    $211–785

  8. Train to Toronto Pearson International Airport, fly to Covington, bus

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Covington (CVG)plane plane YYZ - CVG
    3. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    9h 5m
    $621–1,059

  9. Train, shuttle to Detroit, fly to Louisville International Airport

    1. Take the train from Guelph to Londontrain train
    2. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    3. Fly from Detroit (DTW) to Louisville International Airport (SDF)plane plane DTW - SDF
    10h 48m
    $161–908

  10. Train to Toronto Pearson International Airport, fly to Indianapolis, bus

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Indianapolis (IND)plane plane YYZ - IND
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    10h 2m
    $442–1,021

  11. Train, shuttle to Detroit, fly to Blue Grass Airport, drive

    1. Take the train from Guelph to Londontrain train
    2. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    3. Fly from Detroit (DTW) to Blue Grass Airport (LEX)plane plane DTW - LEX
    4. Drive from Lexington-Airport-LEX to Louisvillecar car
    10h 54m
    $138–684

  12. Train, bus #2

    1. Take the train from Guelph to Londontrain train
    2. Take the bus from London to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Cincinnati Bus Stationbus bus
    4. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    15h 57m
    $71–296

  13. Bus via Indianapolis

    1. Take the bus from Kitchener to Detroit Bus Stationbus bus
    2. Take the bus from Detroit, MI to Indianapolis, INbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    16h 54m
    $83–169

Guelph to Louisville by train, car, and bus

Calendar7Weekly Services
Duration15h 13mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Guelph to Louisville.ExpandLaunch map view
  • Distance: 541.3 mi
  • Duration: 9h 5m

What companies run services between Guelph, ON, Canada and Louisville, KY, USA?

You can take a bus from Guelph Central GO Bus to Louisville, KY Bus Station via Victoria / Bingemans Centre Dr., Kitchener, Detroit Bus Station, Cincinnati Bus Station, and Greyhound Station Cincinnati in around 15h 59m.

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