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How to get fromGuelph to Louisvilleby train, bus, car, plane, bus (Flixbus, Greyhound), or shuttle

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There are 12 ways to get from Guelph to Louisville by train, bus, car, plane, bus (Flixbus, Greyhound), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus via Detroit

    best
    1. Take the train from Guelph to Londontrain train
    2. Take the train from London to Windsortrain train
    3. Take the bus from Detroit Bus Station to Louisville Bus Stationbus bus
    13h 54m
    $103–437

  2. Bus via Akron

    cheapest
    1. Take the bus from Guelph Central GO Bus to Winston Churchill Transitway Stationbus bus 29
    2. Take the bus from Mississauga to Buffalobus bus
    3. Take the bus from Buffalo to Akronbus bus
    4. Take the bus from Akron to Louisvillebus bus
    17h 52m
    $85–214

  3. Drive  539.8 mi

    1. Drive from Guelph to Louisvillecar car 539.8 mi
    9h 24m
    $124–179

  4. Train to Toronto Pearson International Airport, fly to Louisville International Airport

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Louisville International Airport (SDF)plane plane YYZ - SDF
    9h 5m
    $96–565

  5. Bus

    1. Take the bus from Kitchener to Detroit Bus Stationbus bus FlixBus N2710
    2. Take the bus from Detroit Bus Station to Louisville Bus Stationbus bus Greyhound US0135 / ...
    15h 34m
    $91–169

  6. Train, bus

    1. Take the train from Guelph to Londontrain train
    2. Take the bus from London to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Louisville Bus Stationbus bus
    15h 47m
    $92–295

  7. Train to Toronto Island Airport, fly to Louisville International Airport

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Fly from Toronto Island Airport (YTZ) to Louisville International Airport (SDF)plane plane YTZ - SDF
    9h 3m
    $121–666

  8. Train, shuttle to Buffalo Niagara International Airport, fly to Louisville International Airport

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    9h 52m
    $211–785

  9. Train to Toronto Pearson International Airport, fly to Covington, bus

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Covington (CVG)plane plane YYZ - CVG
    3. Take the bus from Cincinnati to Louisvillebus bus
    9h 2m
    $621–1,059

  10. Train, shuttle to Detroit, fly to Louisville International Airport

    1. Take the train from Guelph to Londontrain train
    2. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    3. Fly from Detroit (DTW) to Louisville International Airport (SDF)plane plane DTW - SDF
    10h 48m
    $160–906

  11. Train to Toronto Pearson International Airport, fly to Indianapolis, bus

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Indianapolis (IND)plane plane YYZ - IND
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    9h 27m
    $352–1,071

  12. Train, shuttle to Detroit, fly to Blue Grass Airport, drive

    1. Take the train from Guelph to Londontrain train
    2. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    3. Fly from Detroit (DTW) to Blue Grass Airport (LEX)plane plane DTW - LEX
    4. Drive from Lexington-Airport-LEX to Louisvillecar car
    10h 54m
    $137–682

Guelph to Louisville by train, car, and bus

Calendar7Weekly Services
Duration13h 54mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

Map of how to get from Guelph to Louisville.ExpandLaunch map view
  • Distance: 542.7 mi
  • Duration: 13h 54m

What companies run services between Guelph, ON, Canada and Louisville, KY, USA?

You can take a bus from Guelph Central GO Bus to Louisville Bus Station via Victoria / Bingemans Centre Dr., Kitchener, and Detroit Bus Station in around 15h 34m.

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