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How to get fromGuelph to St. Louisby train, plane, train (Amtrak), bus (Flixbus, Greyhound), car, shuttle, or bus

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There are 9 ways to get from Guelph to St. Louis by train, plane, train (Amtrak), bus (Flixbus, Greyhound), car, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Toronto Pearson International Airport, fly

    best
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    6h 24m
    $514–1,416

  2. Bus

    cheapest
    1. Take the bus from Kitchener to Detroit Bus Stationbus bus
    2. Take the bus from Detroit, MI to Indianapolis, INbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    18h 22m
    $99–199

  3. Train

    1. Take the train from Guelph to Sarniatrain train
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    17h
    $226–580

  4. Drive 702.5 mi

    1. Drive from Guelph to St. Louiscar car 702.5 mi
    12h 14m
    $161–233

  5. Train to Toronto Island Airport, fly

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Fly from Toronto Island Airport (YTZ) to Lambert–St. Louis International Airport (STL)plane plane YTZ - STL
    8h 43m
    $493–966

  6. Train, shuttle to Buffalo Niagara International Airport, fly

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    9h 27m
    $254–936

  7. Train to London International Airport, fly

    1. Take the train from Guelph to Londontrain train
    2. Fly from London International Airport (YXU) to Lambert–St. Louis International Airport (STL)plane plane YXU - STL
    11h
    $263–1,466

  8. Train, shuttle to Detroit, fly

    1. Take the train from Guelph to Londontrain train
    2. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    3. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    10h 26m
    $468–1,208

  9. Train, bus

    1. Take the train from Guelph to Sarniatrain train
    2. Take the bus from Port Huron Station to Chicago Union Stationbus bus
    3. Take the train from Chicago Union Station to St. Louistrain train
    17h
    $246–550

Guelph to St. Louis by train and car

Calendar7Weekly Services
Duration17hAverage Duration
Ticket$226Cheapest Price
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Questions & Answers

Map of how to get from Guelph to St. Louis.ExpandLaunch map view
  • Distance: 707 mi
  • Duration: 6h 24m

What companies run services between Guelph, ON, Canada and St. Louis, MO, USA?

You can take a train from Guelph to St. Louis via Sarnia, Port Huron Station, and Chicago Union Station in around 17h. Alternatively, you can take a bus from Guelph Central GO Bus to St Louis Bus Station via Victoria / Bingemans Centre Dr., Kitchener, Detroit, MI, and Indianapolis Union Station in around 18h 22m.

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