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How to get fromHamilton to Knoxvilleby bus, plane, bus (Flixbus), train, car, or shuttle

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There are 11 ways to get from Hamilton to Knoxville by bus, plane, bus (Flixbus), train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Toronto Pearson International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from King St. W. @ Summers Ln. to Pearson International Airport Terminal 1bus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS)plane plane YYZ - TYS
    7h 40m
    $174–680

  2. Drive 699 mi

    cheapest
    1. Drive from Hamilton to Knoxvillecar car 699 mi
    11h 57m
    $160–231

  3. Bus

    1. Take the bus from Hamilton GO Centre Bus to Union Station Bus Terminalbus bus 16 / ...
    2. Take the bus from Toronto to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    25h 56m
    $272–403

  4. Train, bus

    1. Take the train from Aldershot to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    27h 2m
    $272–488

  5. Train to Toronto Island Airport, fly to Mcghee Tyson Airport

    1. Take the train from West Harbour GO to Union Station GOtrain train
    2. Fly from Toronto Island Airport (YTZ) to Mcghee Tyson Airport (TYS)plane plane YTZ - TYS
    8h 41m
    $194–781

  6. Bus, shuttle to Buffalo Niagara International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from King St. W. @ Summers Ln. to Pearson International Airport Terminal 1bus bus
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    8h 53m
    $324–1,150

  7. Bus to Toronto Pearson International Airport, fly to Nashville, drive

    1. Take the bus from King St. W. @ Summers Ln. to Pearson International Airport Terminal 1bus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Nashville (BNA)plane plane YYZ - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    8h 9m
    $169–1,460

  8. Train to Detroit, fly to Mcghee Tyson Airport

    1. Take the train from Aldershot to Windsortrain train
    2. Fly from Detroit (DTW) to Mcghee Tyson Airport (TYS)plane plane DTW - TYS
    9h 10m
    $232–1,029

  9. Bus to Toronto Pearson International Airport, fly to Covington, drive

    1. Take the bus from King St. W. @ Summers Ln. to Pearson International Airport Terminal 1bus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Covington (CVG)plane plane YYZ - CVG
    3. Drive from Covington (CVG) to Knoxvillecar car
    9h 3m
    $654–1,075

  10. Train, bus via Farragut

    1. Take the train from Aldershot to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    27h 21m
    $317–578

  11. Bus, train

    1. Take the bus from Burlington GO Bus to Niagara Falls Bus Terminalbus bus 12
    2. Take the train from Niagara Falls to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    27h 44m
    $346–578

Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS) flights

Calendar146Weekly Planes
Duration5h 30mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

Map of how to get from Hamilton to Knoxville.ExpandLaunch map view
  • Distance: 645.4 mi
  • Duration: 7h 40m

What companies run services between Hamilton, ON, Canada and Knoxville, TN, USA?

You can take a bus from Hamilton GO Centre Bus to Knoxville via Union Station Bus Terminal, Toronto, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 25h 56m.

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