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How to get fromHamilton to St. Louisby bus, plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus (Greyhound)

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There are 7 ways to get from Hamilton to St. Louis by bus, plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Toronto Pearson International Airport, fly

    best
    1. Take the bus from King St. W. @ Summers Ln. to Pearson International Airport Terminal 1bus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    6h 5m
    $91–473

  2. Train via Detroit

    1. Take the train from Aldershot to Windsortrain train
    2. Take the train from Detroit to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    16h 55m
    $355–688

  3. Bus via Indianapolis

    1. Take the bus from Hamilton GO Centre Bus to Square Onebus bus 40 / ...
    2. Take the bus from Mississauga to Detroit Bus Stationbus bus
    3. Take the bus from Detroit to Indianapolisbus bus
    4. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    19h 23m
    $99–198

  4. Drive  708.3 mi

    1. Drive from Hamilton to St. Louiscar car 708.3 mi
    12h 2m
    $163–235

  5. Train, bus to Buffalo Niagara International Airport, fly

    1. Take the train from West Harbour GO to Niagara Falls GOtrain train
    2. Take the bus from Niagara Falls to Buffalobus bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    9h 42m
    $126–599

  6. Train

    1. Take the train from Aldershot to Buffalotrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    22h 16m
    $465–855

  7. Bus

    1. Take the bus from Burlington GO Bus to Niagara Falls Bus Terminalbus bus 12
    2. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    3. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus
    26h 55m
    $166–424

Hamilton to St. Louis by bus and foot

Calendar5Weekly Services
Duration19h 23mAverage Duration
Ticket$99Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hamilton to St. Louis.ExpandLaunch map view
  • Distance: 709.1 mi
  • Duration: 6h 5m

What companies run services between Hamilton, ON, Canada and St. Louis, MO, USA?

You can take a train from West Harbour GO to St. Louis via Aldershot GO, Aldershot, Windsor, Detroit, and Chicago Union Station in around 16h 55m. Alternatively, you can take a bus from Hamilton GO Centre Bus to St Louis Bus Station via Square One, Mississauga, Detroit, and Indianapolis Union Station in around 19h 23m.

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