There are 5 ways to get from Hannibal to Chicago by train (Amtrak), car, shuttle, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Quincy Amtrak Station to Chicago Union Stationtrain Carl Sandburg / ...
4h 51m$136–258Drive 295.8 mi
cheapest- Drive from Hannibal to Chicagocar 295.8 mi
5h 10m$54–78Shuttle to Lambert–St. Louis International Airport, fly to Chicago Midway International Airport
- Take a shuttle bus from Hannibal to St. Louis
- Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane STL - MDW
5h 2m$70–378Shuttle to Columbia Regional Airport, fly to Chicago O'Hare International Airport
- Take a shuttle bus from Hannibal to Columbia
- Fly from Columbia Regional Airport (COU) to Chicago O'Hare International Airport (ORD)plane COU - ORD
5h 21m$102–339Shuttle to Lambert–St. Louis International Airport, fly to Chicago O'Hare International Airport
- Take a shuttle bus from Hannibal to St. Louis
- Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane STL - ORD
5h 25m$340–728
Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW) flights
Comparing Your Travel Options
The cheapest way to get from Hannibal to Chicago is to drive which costs $50 - $80 and takes 5h 10m.
The fastest way to get from Hannibal to Chicago is to train which takes 4h 51m and costs $130 - $260.
No, there is no direct train from Hannibal station to Chicago station. However, there are services departing from Quincy Amtrak Station and arriving at Chicago Union Station via . The journey, including transfers, takes approximately 4h 51m.
The distance between Hannibal and Chicago is 332 miles. The road distance is 297.6 miles.
The best way to get from Hannibal to Chicago without a car is to train which takes 4h 51m and costs $130 - $260.
It takes approximately 4h 51m to get from Hannibal to Chicago, including transfers.
Hannibal to Chicago train services, operated by Amtrak, depart from Quincy Amtrak Station.
Hannibal to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Hannibal to Chicago is 298 miles. It takes approximately 5h 10m to drive from Hannibal to Chicago.
There are 1280+ hotels available in Chicago.
What companies run services between Hannibal, MO, USA and Chicago, IL, USA?
Amtrak operates a train from Quincy Amtrak Station to Chicago Union Station twice daily. Tickets cost $70–180 and the journey takes 4h 21m.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- $50–350
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Quincy Amtrak Station to Chicago Union Station
- Ave. Duration
- 4h 21m
- Frequency
- Twice daily
- Estimated price
- $70–180
- Website
- Amtrak
- Phone
- +1-888-875-6287
- Website
- Oats Transit
Shuttle from Hannibal to St. Louis
- Ave. Duration
- 1h 51m
- Frequency
- Twice a week
- Estimated price
- $4–7
- Website
- Oats Transit
- Schedules at
- Oats Transit Schedules
Shuttle from Hannibal to Columbia
- Ave. Duration
- 1h 45m
- Frequency
- Twice a week
- Estimated price
- $4–6
- Website
- Oats Transit
- Schedules at
- Oats Transit Schedules
Shuttle from Hannibal to St. Louis
- Ave. Duration
- 1h 51m
- Frequency
- Twice a week
- Estimated price
- $4–7
- Website
- Oats Transit
- Schedules at
- Oats Transit Schedules
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