There are 4 ways to get from Hannibal to Des Moines by bus (Greyhound), car, shuttle, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus (Greyhound)
best- Take the bus from Quincy Public Transit Hub to Des Moinesbus Greyhound US0153S
6h 21m$100–156Drive 218 mi
cheapest- Drive from Hannibal to Des Moinescar 218 mi
4h 34m$40–58Shuttle to Lambert–St. Louis International Airport, fly
- Take a shuttle bus from Hannibal to St. Louis
- Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane STL - DSM
6h 46m$181–813Shuttle to Columbia Regional Airport, fly
- Take a shuttle bus from Hannibal to Columbia
- Fly from Columbia Regional Airport (COU) to Des Moines (DSM)plane COU - DSM
7h 28m$208–724
Lambert–St. Louis International Airport (STL) to Des Moines (DSM) flights
Questions & Answers
The cheapest way to get from Hannibal to Des Moines is to drive which costs $40 - $60 and takes 4h 34m.
The fastest way to get from Hannibal to Des Moines is to drive which takes 4h 34m and costs $40 - $60.
No, there is no direct bus from Hannibal to Des Moines. However, there are services departing from Quincy Public Transit Hub and arriving at Des Moines via . The journey, including transfers, takes approximately 6h 21m.
The distance between Hannibal and Des Moines is 303 miles. The road distance is 219.3 miles.
The best way to get from Hannibal to Des Moines without a car is to bus which takes 6h 21m and costs $95 - $160.
It takes approximately 6h 21m to get from Hannibal to Des Moines, including transfers.
Hannibal to Des Moines bus services, operated by Greyhound USA, depart from Quincy Public Transit Hub station.
Hannibal to Des Moines bus services, operated by Greyhound USA, arrive at Des Moines station.
Yes, the driving distance between Hannibal to Des Moines is 219 miles. It takes approximately 4h 34m to drive from Hannibal to Des Moines.
There are 263+ hotels available in Des Moines.
What companies run services between Hannibal, MO, USA and Des Moines, IA, USA?
Greyhound USA operates a bus from Quincy Public Transit Hub to Des Moines once daily. Tickets cost $40–85 and the journey takes 5h 50m.
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- $130–750
Flights from Lambert–St. Louis International Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 5h 1m
- When
- Every day
- Estimated price
- $220–1,100
Flights from Columbia Regional Airport to Des Moines via Charlotte
- Ave. Duration
- 5h 39m
- When
- Sunday
- Estimated price
- $200–900
Flights from Columbia Regional Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 6h 31m
- When
- Every day
- Estimated price
- $110–600
Flights from Columbia Regional Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 6h 45m
- When
- Every day
- Estimated price
- $160–800
- Website
- united.com
Flights from Lambert–St. Louis International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $130–750
Flights from Lambert–St. Louis International Airport to Des Moines via Denver
- Ave. Duration
- 5h 32m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $250–1,100
Flights from Columbia Regional Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- $110–600
Flights from Columbia Regional Airport to Des Moines via Denver
- Ave. Duration
- 7h 15m
- When
- Every day
- Estimated price
- $180–850
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Des Moines via Minneapolis
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $150–800
Flights from Lambert–St. Louis International Airport to Des Moines via Atlanta
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $230–1,100
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Des Moines via Chicago Midway
- Ave. Duration
- 4h 11m
- When
- Sunday, Monday, Thursday, Friday, Tuesday, and Wednesday
- Estimated price
- $130–750
Flights from Lambert–St. Louis International Airport to Des Moines via Denver
- Ave. Duration
- 5h 15m
- When
- Sunday, Monday, Thursday, and Friday
- Estimated price
- $250–1,100
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Quincy Public Transit Hub to Des Moines
- Ave. Duration
- 5h 50m
- Frequency
- Once daily
- Estimated price
- $40–85
- Website
- https://www.greyhound.com/
- Phone
- +1-888-875-6287
- Website
- oatstransit.org
Shuttle from Hannibal to St. Louis
- Ave. Duration
- 1h 51m
- Frequency
- Twice a week
- Estimated price
- $4–7
- Website
- https://www.oatstransit.org
- Schedules at
- https://www.oatstransit.org/schedules
Shuttle from Hannibal to Columbia
- Ave. Duration
- 1h 45m
- Frequency
- Twice a week
- Estimated price
- $4–6
- Website
- https://www.oatstransit.org
- Schedules at
- https://www.oatstransit.org/schedules
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