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How to get fromHannibal to Indianapolisby train, bus, train (Amtrak), car, shuttle, or plane

Find Transport to Indianapolis

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There are 6 ways to get from Hannibal to Indianapolis by train, bus, train (Amtrak), car, shuttle, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Quincy Amtrak Station to Galesburg Amtrak Stationtrain train Illinois Zephyr / ...
    2. Take the bus from Galesburg to Indianapolis Union Stationbus bus Greyhound US0157S
    7h 43m
    $141–228

  2. Shuttle, bus

    cheapest
    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus Palmyra
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    8h 17m
    $53–83

  3. Train (Amtrak)

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train Carl Sandburg / ...
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    10h 45m
    $186–378

  4. Drive  305.2 mi

    1. Drive from Hannibal to Indianapoliscar car 305.2 mi
    5h 10m
    $56–81

  5. Shuttle to Lambert–St. Louis International Airport, fly

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    7h 31m
    $880–925

  6. Shuttle to Columbia Regional Airport, fly

    1. Take a shuttle bus from Hannibal to Columbiashuttle bus
    2. Fly from Columbia Regional Airport (COU) to Indianapolis (IND)plane plane COU - IND
    8h
    $152–636

Lambert–St. Louis International Airport (STL) to Indianapolis (IND) flights

Calendar151Weekly Planes
Duration4h 16mAverage Duration
Ticket$91Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Hannibal to Indianapolis.ExpandLaunch map view
  • Distance: 423.2 mi
  • Duration: 7h 43m

What companies run services between Hannibal, MO, USA and Indianapolis, IN, USA?

You can take a vehicle from Hannibal to Indianapolis via Quincy Amtrak Station and Chicago Union Station in around 10h 45m.

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