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How to get fromHannibal to Indianapolisby train, bus, train (Amtrak), car, shuttle, plane, or taxi

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There are 7 ways to get from Hannibal to Indianapolis by train, bus, train (Amtrak), car, shuttle, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Quincy Amtrak Station to Galesburg Amtrak Stationtrain train Illinois Zephyr / ...
    2. Take the bus from Galesburg to Indianapolis Union Stationbus bus Greyhound US0157S
    7h 43m
    $186–278

  2. Drive  305.2 mi

    cheapest
    1. Drive from Hannibal to Indianapoliscar car 305.2 mi
    5h 10m
    $56–81

  3. Train (Amtrak)

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train Carl Sandburg / ...
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    10h 45m
    $326–508

  4. Shuttle to Lambert–St. Louis International Airport, fly

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    7h 36m
    $880–925

  5. Shuttle, bus

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus Palmyra
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    8h 17m
    $58–88

  6. Shuttle to Columbia Regional Airport, fly

    1. Take a shuttle bus from Hannibal to Columbiashuttle bus
    2. Fly from Columbia Regional Airport (COU) to Indianapolis (IND)plane plane COU - IND
    8h 10m
    $152–636

  7. Taxi to Quincy Regional Airport, fly

    1. Take the taxi from Hannibal to Quincy Regional Airport (UIN)taxi taxi
    2. Fly from Quincy Regional Airport (UIN) to Indianapolis (IND)plane plane UIN - IND
    5h 36m
    $199–742

Lambert–St. Louis International Airport (STL) to Indianapolis (IND) flights

Calendar125Weekly Planes
Duration4h 10mAverage Duration
Ticket$91Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hannibal to Indianapolis.ExpandLaunch map view
  • Distance: 423.2 mi
  • Duration: 7h 43m

What companies run services between Hannibal, MO, USA and Indianapolis, IN, USA?

You can take a vehicle from Hannibal to Indianapolis via Quincy Amtrak Station and Chicago Union Station in around 10h 45m.

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