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How to get fromHannibal to Knoxvilleby shuttle, plane, train, bus, or car

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There are 7 ways to get from Hannibal to Knoxville by shuttle, plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle, fly to Mcghee Tyson Airport

    best
    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    6h 47m
    $213–993

  2. Drive  585.9 mi

    cheapest
    1. Drive from Hannibal to Knoxvillecar car 585.9 mi
    10h 29m
    $107–155

  3. Train, bus

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 36m
    $554–1,061

  4. Shuttle, bus

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 27m
    $359–534

  5. Shuttle, fly to Nashville, drive

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 14m
    $188–823

  6. Train, bus via Ossining

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to Grand Central Terminaltrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 14m
    $520–989

  7. Train, bus #2

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 46m
    $380–603

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar144Weekly Planes
Duration4h 48mAverage Duration
Ticket$141Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hannibal to Knoxville.ExpandLaunch map view
  • Distance: 532.3 mi
  • Duration: 6h 47m

What companies run services between Hannibal, MO, USA and Knoxville, TN, USA?

There is no direct connection from Hannibal to Knoxville. However, you can take the taxi to Hannibal, take the shuttle to St. Louis, walk to NORTH HANLEY station, take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take a vehicle from Hannibal to Knoxville via Quincy Amtrak Station, Chicago Union Station, Ny Moynihan Train Hall At Penn Station, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 39h 36m.

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