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How to get fromHannibal to Knoxvilleby bus, plane, train, bus (Greyhound), car, taxi, or bus (Flixbus)

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There are 9 ways to get from Hannibal to Knoxville by bus, plane, train, bus (Greyhound), car, taxi, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Lambert–St. Louis International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Hannibal to Saint Louisbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    7h 7m
    $242–952

  2. Drive 585.9 mi

    cheapest
    1. Drive from Hannibal to Knoxvillecar car 585.9 mi
    10h 29m
    $107–155

  3. Train, bus

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 36m
    $652–1,179

  4. Bus

    1. Take the bus from Hannibal to Saint Louisbus bus
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 38m
    $405–660

  5. Taxi to Quincy Regional Airport, fly to Nashville, drive

    1. Take the taxi from Hannibal to Quincy Regional Airport (UIN)taxi taxi
    2. Fly from Quincy Regional Airport (UIN) to Nashville (BNA)plane plane UIN - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 50m
    $221–604

  6. Bus to Lambert–St. Louis International Airport, fly to Nashville, drive

    1. Take the bus from Hannibal to Saint Louisbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 51m
    $167–602

  7. Taxi to Quincy Regional Airport, fly to Mcghee Tyson Airport

    1. Take the taxi from Hannibal to Quincy Regional Airport (UIN)taxi taxi
    2. Fly from Quincy Regional Airport (UIN) to Mcghee Tyson Airport (TYS)plane plane UIN - TYS
    5h 5m
    $256–854

  8. Train, bus via Ossining

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 14m
    $607–1,106

  9. Bus via Auburn Gresham

    1. Take the bus from Hannibal to Saint Louisbus bus
    2. Take the bus from St Louis Bus Station to Chicagobus bus
    3. Take the bus from Chicago to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    47h 27m
    $371–547

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar113Weekly Planes
Duration5h 2mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Hannibal to Knoxville.ExpandLaunch map view
  • Distance: 525.1 mi
  • Duration: 7h 7m

What companies run services between Hannibal, MO, USA and Knoxville, TN, USA?

You can take a vehicle from Hannibal to Knoxville via Hannibal, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 41h 38m.

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