Rome2Rio

How to get fromHannibal to Knoxvilleby shuttle, plane, train, bus, car, or taxi

Find Transport to Knoxville

See all options

There are 10 ways to get from Hannibal to Knoxville by shuttle, plane, train, bus, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Lambert–St. Louis International Airport, fly to Mcghee Tyson Airport

    best
    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    7h
    $213–993

  2. Drive  585.9 mi

    cheapest
    1. Drive from Hannibal to Knoxvillecar car 585.9 mi
    10h 29m
    $107–155

  3. Train, bus

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 36m
    $589–1,251

  4. Shuttle, bus

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 27m
    $369–544

  5. Taxi to Quincy Regional Airport, fly to Nashville, drive

    1. Take the taxi from Hannibal to Quincy Regional Airport (UIN)taxi taxi
    2. Fly from Quincy Regional Airport (UIN) to Nashville (BNA)plane plane UIN - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 50m
    $247–740

  6. Shuttle to Columbia Regional Airport, fly to Mcghee Tyson Airport

    1. Take a shuttle bus from Hannibal to Columbiashuttle bus
    2. Fly from Columbia Regional Airport (COU) to Mcghee Tyson Airport (TYS)plane plane COU - TYS
    7h 45m
    $290–1,104

  7. Taxi to Quincy Regional Airport, fly to Mcghee Tyson Airport

    1. Take the taxi from Hannibal to Quincy Regional Airport (UIN)taxi taxi
    2. Fly from Quincy Regional Airport (UIN) to Mcghee Tyson Airport (TYS)plane plane UIN - TYS
    5h 55m
    $292–1,060

  8. Shuttle to Lambert–St. Louis International Airport, fly to Nashville, drive

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 14m
    $198–823

  9. Train, bus via Ossining

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to Grand Central Terminaltrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 14m
    $545–1,129

  10. Train, bus #2

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 46m
    $395–643

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar119Weekly Planes
Duration4h 42mAverage Duration
Ticket$144Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Hannibal to Knoxville.ExpandLaunch map view
  • Distance: 532.3 mi
  • Duration: 7h

What companies run services between Hannibal, MO, USA and Knoxville, TN, USA?

There is no direct connection from Hannibal to Knoxville. However, you can take the taxi to Hannibal, take the shuttle to St. Louis, walk to NORTH HANLEY station, take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take a vehicle from Hannibal to Knoxville via Quincy Amtrak Station, Chicago Union Station, Ny Moynihan Train Hall At Penn Station, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 39h 36m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound