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How to get fromHannibal to Lexingtonby shuttle, bus, car, train, plane, or taxi

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There are 9 ways to get from Hannibal to Lexington by shuttle, bus, car, train, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle, bus, drive

    best
    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Corydon, INbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    14h 18m
    $163–236

  2. Drive 453.5 mi

    cheapest
    1. Drive from Hannibal to Lexingtoncar car 453.5 mi
    7h 50m
    $83–120

  3. Train, bus, drive via Lafayette (Amtrak)

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    19h 11m
    $248–430

  4. Shuttle to Lambert–St. Louis International Airport, fly

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    9h 39m
    $206–1,044

  5. Bus, drive

    1. Take the bus from Quincy Public Transit Hub to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    15h 41m
    $154–237

  6. Train, bus, drive (Amtrak)

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    17h 44m
    $227–357

  7. Shuttle to Columbia Regional Airport, fly

    1. Take a shuttle bus from Hannibal to Columbiashuttle bus
    2. Fly from Columbia Regional Airport (COU) to Blue Grass Airport (LEX)plane plane COU - LEX
    9h 46m
    $223–905

  8. Taxi to Quincy Regional Airport, fly

    1. Take the taxi from Hannibal to Quincy Regional Airport (UIN)taxi taxi
    2. Fly from Quincy Regional Airport (UIN) to Blue Grass Airport (LEX)plane plane UIN - LEX
    9h 3m
    $203–836

  9. Drive to Burlington Municipal Airport, fly

    1. Drive from Hannibal to Burlington Municipal Airport (BRL)car car
    2. Fly from Burlington Municipal Airport (BRL) to Blue Grass Airport (LEX)plane plane BRL - LEX
    11h 29m
    $139–726

Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX) flights

Calendar104Weekly Planes
Duration4h 58mAverage Duration
Ticket$177Cheapest Price
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Questions & Answers

Map of how to get from Hannibal to Lexington.ExpandLaunch map view
  • Distance: 495.4 mi
  • Duration: 14h 18m

What companies run services between Hannibal, MO, USA and Lexington, KY, USA?

There is no direct connection from Hannibal to Lexington. However, you can take the taxi to Hannibal, take the shuttle to St. Louis, walk to NORTH HANLEY station, take the train to CIVIC CENTER station, walk to St Louis Bus Station, take the bus to Evansville Bus Station, take the bus to Corydon, IN, take the taxi to Shawnee Park @ Northwestern Pkwy, take the line 15 bus to Market @ S 6th, walk to S 5th @ W Jefferson, take the line 31 bus to Middletown Station @ Target, then drive to Lexington. Alternatively, you can take a vehicle from Hannibal to Lexington via Quincy Amtrak Station, Chicago Union Station, Lafayette Amtrak Station, Lafayette Amtrak Station, Louisville, KY, Roy Wilkins @ W Broadway, Chestnut @ 8th, S 5th @ W Jefferson, and Middletown Station @ Target in around 19h 11m.

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