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How to get fromHannibal to Lexingtonby shuttle, bus, car, train, or plane

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There are 7 ways to get from Hannibal to Lexington by shuttle, bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle, bus, drive

    best
    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    13h 51m
    $93–222

  2. Drive  453.5 mi

    cheapest
    1. Drive from Hannibal to Lexingtoncar car 453.5 mi
    7h 50m
    $83–120

  3. Train, bus, drive via Chicago (Amtrak)

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    17h 45m
    $214–407

  4. Shuttle to Lambert–St. Louis International Airport, fly

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    9h 25m
    $95–465

  5. Train, bus, drive

    1. Take the train from Quincy Amtrak Station to Galesburg Amtrak Stationtrain train
    2. Take the bus from Galesburg to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    14h 11m
    $177–297

  6. Train, bus, drive #2

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    15h 44m
    $195–357

  7. Shuttle to Columbia Regional Airport, fly

    1. Take a shuttle bus from Hannibal to Columbiashuttle bus
    2. Fly from Columbia Regional Airport (COU) to Blue Grass Airport (LEX)plane plane COU - LEX
    9h 42m
    $132–476

Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX) flights

Calendar124Weekly Planes
Duration5h 7mAverage Duration
Ticket$76Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Hannibal to Lexington.ExpandLaunch map view
  • Distance: 493.6 mi
  • Duration: 13h 51m

What companies run services between Hannibal, MO, USA and Lexington, KY, USA?

There is no direct connection from Hannibal to Lexington. However, you can take the taxi to Hannibal, take the shuttle to St. Louis, walk to NORTH HANLEY station, take the train to CIVIC CENTER station, walk to St Louis Bus Station, take the bus to Evansville Bus Station, take the bus to Louisville, KY, walk to Chestnut @ 13th, take the line 21 bus to Chestnut @ 8th, walk to S 5th @ W Jefferson, take the line 31 bus to Middletown Station @ Target, then drive to Lexington. Alternatively, you can take a vehicle from Hannibal to Lexington via Quincy Amtrak Station, Chicago Union Station, Lafayette Amtrak Station, Lafayette Amtrak Station, Louisville, KY, Chestnut @ 13th, Chestnut @ 8th, S 5th @ W Jefferson, and Middletown Station @ Target in around 17h 45m.

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