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How to get fromHannibal to Sioux Fallsby shuttle, plane, train, bus, or car

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There are 6 ways to get from Hannibal to Sioux Falls by shuttle, plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Lambert–St. Louis International Airport, fly

    best
    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Sioux Falls (FSD)plane plane STL - FSD
    8h 23m
    $100–475

  2. Drive  498.7 mi

    cheapest
    1. Drive from Hannibal to Sioux Fallscar car 498.7 mi
    8h 13m
    $91–132

  3. Train, bus

    1. Take the train from Quincy Amtrak Station to Galesburg Amtrak Stationtrain train
    2. Take the bus from Galesburg to Des Moinesbus bus
    3. Take the bus from Des Moines to Omaha, NEbus bus
    4. Take the bus from Omaha to Sioux Fallsbus bus
    17h 31m
    $204–330

  4. Train, bus via Saint Paul

    1. Take the train from Quincy Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from Minneapolis to Fairmontbus bus
    4. Take the bus from Fairmont to Sioux Fallsbus bus
    21h 37m
    $331–638

  5. Shuttle to Columbia Regional Airport, fly

    1. Take a shuttle bus from Hannibal to Columbiashuttle bus
    2. Fly from Columbia Regional Airport (COU) to Sioux Falls (FSD)plane plane COU - FSD
    9h 43m
    $147–506

  6. Shuttle, bus

    1. Take a shuttle bus from Hannibal to St. Louisshuttle bus
    2. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    3. Take the bus from Kansas City to Sioux Fallsbus bus
    18h 45m
    $150–230

Lambert–St. Louis International Airport (STL) to Sioux Falls (FSD) flights

Calendar124Weekly Planes
Duration5h 27mAverage Duration
Ticket$83Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hannibal to Sioux Falls.ExpandLaunch map view
  • Distance: 590.8 mi
  • Duration: 8h 23m

What companies run services between Hannibal, MO, USA and Sioux Falls, SD, USA?

There is no direct connection from Hannibal to Sioux Falls. However, you can take the taxi to Hannibal, take the shuttle to St. Louis, walk to NORTH HANLEY station, take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Sioux Falls (FSD), walk to 4th Ave/Wells Fargo crosswalk, then take the line 8 bus to Cliff/3rd NW corner. Alternatively, you can take a vehicle from Hannibal to The Bus Stop via Quincy Amtrak Station, Galesburg Amtrak Station, Galesburg, Des Moines, Omaha, Sioux Falls, and Maple/Career NE corner in around 17h 31m.

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