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How to get fromHarrisburg Airport (MDT) to Chicagoby plane, taxi, train (Amtrak), bus (Flixbus), bus (Greyhound), or car

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There are 6 ways to get from Harrisburg Airport (MDT) to Chicago by plane, taxi, train (Amtrak), bus (Flixbus), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    2h 55m
    $119–628

  2. Taxi to Lancaster, fly

    1. Take the taxi from Harrisburg-Airport-MDT to Lancaster-Airport-LNStaxi taxi
    2. Fly from Lancaster (LNS) to Chicago O'Hare International Airport (ORD)plane plane LNS - ORD
    3h 47m
    $147–411

  3. Train (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    17h 37m
    $226–482

  4. Bus (Flixbus)

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    17h 54m
    $121–202

  5. Bus via Baltimore (Greyhound)

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    22h 49m
    $122–244

  6. Drive 663.5 mi

    1. Drive from Harrisburg Airport (MDT) to Chicagocar car 663.5 mi
    10h 54m
    $122–175

Harrisburg Airport (MDT) to Chicago by bus, foot, and train (Amtrak)

Calendar7Weekly Services
Duration17h 37mAverage Duration
Ticket$226Cheapest Price
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Questions & Answers

Map of how to get from Harrisburg Airport (MDT) to Chicago.ExpandLaunch map view
  • Distance: 610.9 mi
  • Duration: 2h 55m

What companies run services between Harrisburg Airport (MDT), USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, you can take a bus from Harrisburg International Airport to Chicago Union Station via S 2nd St & Chestnut St NB, Harrisburg, and Pittsburgh Amtrak Station in around 17h 37m.

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