There are 7 ways to get from Harrisburg to Chicago by plane, train (Amtrak), bus (Flixbus), car, bus, train, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Harrisburg International Airport to Chicago O'Hare International Airport
best- Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane MDT - ORD
4h 20m$58–317Train (Amtrak)
- Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain Pennsylvanian
- Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain Floridian
16h 15m$215–467Bus (Flixbus)
- Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus FlixBus N2640 / ...
16h 30m$110–190Drive 656.9 mi
- Drive from Harrisburg to Chicagocar 656.9 mi
10h 49m$120–174Bus to Penn State University Park Airport, fly to Chicago O'Hare International Airport
- Take the bus from Harrisburg Bus Station to State College Regional Airportbus
- Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane SCE - ORD
5h 24m$66–327Train to Philadelphia International Airport, fly to Chicago Midway International Airport
- Take the train from Harrisburg to 30th Street Stationtrain
- Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)plane PHL - MDW
6h 5m$186–444Bus via Baltimore (Greyhound)
- Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus Greyhound US0430
- Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus Greyhound US0164
21h 25m$122–242
Harrisburg to Chicago by train (Amtrak)
Questions & Answers
The cheapest way to get from Harrisburg to Chicago is to bus which costs $110 - $190 and takes 16h 30m.
The fastest way to get from Harrisburg to Chicago is to fly which takes 4h 20m and costs $55 - $320.
Yes, there is a direct bus departing from Harrisburg Bus Station station and arriving at Chicago Bus Station station. Services depart once daily, and operate every day. The journey takes approximately 16h 30m.
No, there is no direct train from Harrisburg to Chicago station. However, there are services departing from Harrisburg and arriving at Chicago Union Station via Pittsburgh Amtrak Station. The journey, including transfers, takes approximately 16h 15m.
The distance between Harrisburg and Chicago is 624 miles. The road distance is 660.7 miles.
The best way to get from Harrisburg to Chicago without a car is to train which takes 16h 15m and costs $210 - $470.
It takes approximately 4h 20m to get from Harrisburg to Chicago, including transfers.
Harrisburg to Chicago bus services, operated by Flixbus USA, depart from Harrisburg Bus Station.
Harrisburg to Chicago train services, operated by Amtrak, depart from Harrisburg station.
The best way to get from Harrisburg to Chicago is to fly which takes 4h 20m and costs $55 - $320. Alternatively, you can train, which costs $210 - $470 and takes 16h 15m, you could also bus, which costs $110 - $190 and takes 16h 30m.
What companies run services between Harrisburg, Dauphin County, PA, USA and Chicago, IL, USA?
American Airlines, United Airlines, and Delta fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, you can take a train from Harrisburg to Chicago Union Station via Pittsburgh Amtrak Station in around 16h 15m.
- Website
- united.com
Flights from Harrisburg International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 12m
- When
- Every day
- Estimated price
- $55–310
Flights from Harrisburg International Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 37m
- When
- Every day
- Estimated price
- $60–320
Flights from Penn State University Park Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 4m
- When
- Every day
- Estimated price
- $50–300
Flights from Penn State University Park Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $60–330
- Website
- southwest.com
Flights from Philadelphia International Airport to Chicago Midway International Airport
- Ave. Duration
- 2h 3m
- When
- Every day
- Estimated price
- $90–500
- Website
- aa.com
Flights from Harrisburg International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 20m
- When
- Every day
- Estimated price
- $55–310
Flights from Harrisburg International Airport to Chicago O'Hare International Airport via Charlotte
- Ave. Duration
- 4h 55m
- When
- Every day
- Estimated price
- $75–380
- Website
- delta.com
Flights from Harrisburg International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 33m
- When
- Every day
- Estimated price
- $55–310
Flights from Philadelphia International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $95–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Harrisburg to Pittsburgh Amtrak Station
- Ave. Duration
- 5h 29m
- Frequency
- Once daily
- Estimated price
- $75–160
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Chicago Union Station
- Ave. Duration
- 9h 46m
- Frequency
- Once daily
- Estimated price
- $140–310
- Website
- Amtrak
Train from Harrisburg to 30th Street Station
- Ave. Duration
- 1h 44m
- Frequency
- Every 2 hours
- Estimated price
- $30–70
- Website
- Amtrak
#mediaviewer/File:Amtrak_%22Pennsylvanian%22_at_Bryn_Mawr,_PA.jpg "Pennsylvanian exterior")
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Harrisburg Bus Station to Chicago Bus Station
- Ave. Duration
- 16h 30m
- Frequency
- Once daily
- Estimated price
- $110–190
- Schedules at
- Flixbus USA
Bus from Harrisburg Bus Station to State College Regional Airport
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $13–23
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Harrisburg Bus Station to Baltimore Downtown Bus Station
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $11–22
- Website
- Greyhound
Bus from Baltimore Downtown Bus Station to Chicago Bus Station
- Ave. Duration
- 18h 40m
- Frequency
- Twice daily
- Estimated price
- $110–220
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Harrisburg to Chicago bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Chicago is 1h behind Harrisburg. It is currently 7:22 PM in Harrisburg and 6:22 PM in Chicago.
Harrisburg to Chicago train services, operated by Amtrak, arrive at Pittsburgh Amtrak Station.
Yes, the driving distance between Harrisburg to Chicago is 661 miles. It takes approximately 10h 49m to drive from Harrisburg to Chicago.
Book your Harrisburg to Chicago train tickets online with Omio.
Book your Harrisburg to Chicago bus tickets online with Omio and FlixBus.
There are 1080+ hotels available in Chicago.