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How to get fromHarrisburg to Durhamby bus (Greyhound, Flixbus), train (Amtrak), car, plane, bus (Greyhound), bus, or train

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There are 7 ways to get from Harrisburg to Durham by bus (Greyhound, Flixbus), train (Amtrak), car, plane, bus (Greyhound), bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the bus from Washington Union Station to Durhambus bus FlixBus N2471 / ...
    10h
    $57–117

  2. Bus via Durham, NC - 3446 Hillsborough Rd

    cheapest
    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the bus from Washington, DC - 2305 Pennsylvania Ave to Durham, NC - 3446 Hillsborough Rdbus bus New York
    10h 25m
    $45–91

  3. Train (Amtrak)

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Take the train from Washington Union Station to Durham Amtrak Stationtrain train
    11h 49m
    $161–936

  4. Drive 367.6 mi

    1. Drive from Harrisburg to Durhamcar car 367.6 mi
    6h 37m
    $68–97

  5. Fly from Harrisburg International Airport

    1. Fly from Harrisburg International Airport (MDT) to Raleigh-Durham International Airport (RDU)plane plane MDT - RDU
    6h 12m
    $62–368

  6. Bus, train

    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the train from Washington Union Station to Durham Amtrak Stationtrain train Carolinian
    12h 11m
    $116–257

  7. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Raleigh-Durham International Airport (RDU)plane plane PHL - RDU
    6h 17m
    $110–445

Harrisburg to Durham by bus

Calendar7Weekly Buses
Duration10hAverage Duration
Ticket$57Cheapest Price
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Questions & Answers

Map of how to get from Harrisburg to Durham.ExpandLaunch map view
  • Distance: 399.2 mi
  • Duration: 10h

What companies run services between Harrisburg, Dauphin County, PA, USA and Durham, NC, USA?

You can take a bus from Harrisburg Bus Station to Durham via Washington Union Station in around 10h. Alternatively, you can take a train from Harrisburg to Durham Amtrak Station via 30th Street Station and Washington Union Station in around 11h 49m.

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