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How to get fromHarrisburg, Pa to Buffaloby bus (Greyhound), train (Amtrak), car, plane, bus, or train

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There are 6 ways to get from Harrisburg, Pa to Buffalo by bus (Greyhound), train (Amtrak), car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Harrisburg, Pa to Scranton, Pabus bus 770
    2. Take the bus from Scranton Bus Station to Buffalobus bus Greyhound US0205 / ...
    9h 55m
    $74–148

  2. Drive  280.8 mi

    cheapest
    1. Drive from Harrisburg, Pa to Buffalocar car 280.8 mi
    5h 32m
    $50–72

  3. Train (Amtrak)

    1. Take the train from Harrisburg to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    13h 4m
    $346–543

  4. Fly from Harrisburg International Airport

    1. Fly from Harrisburg International Airport (MDT) to Buffalo Niagara International Airport (BUF)plane plane MDT - BUF
    6h 11m
    $91–580

  5. Bus via Sandy

    1. Take the bus from Harrisburg, Pa to Dubois, Pabus bus 731
    2. Take the bus from DuBois to Buffalobus bus Fab510
    10h 25m
    $57–198

  6. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    6h 5m
    $173–918

Harrisburg, Pa to Buffalo by bus

Calendar7Weekly Buses
Duration9h 55mAverage Duration
Ticket$74Cheapest Price
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Comparing Your Travel Options

Map of how to get from Harrisburg, Pa to Buffalo.ExpandLaunch map view
  • Distance: 391.7 mi
  • Duration: 9h 55m

What companies run services between Harrisburg, Pa, PA, USA and Buffalo, NY, USA?

You can take a bus from Harrisburg, Pa to Buffalo via Scranton Bus Station in around 9h 55m. Alternatively, you can take a train from Harrisburg to Buffalo via Ny Moynihan Train Hall At Penn Station in around 13h 4m.

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