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How to get fromHarrisburg, Pa to Chicagoby plane, train (Amtrak), bus (Flixbus), car, bus, train, or bus (Greyhound)

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There are 7 ways to get from Harrisburg, Pa to Chicago by plane, train (Amtrak), bus (Flixbus), car, bus, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Harrisburg International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    4h 21m
    $113–657

  2. Bus to Penn State University Park Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Harrisburg Bus Station to State College Regional Airportbus bus
    2. Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane plane SCE - ORD
    5h 24m
    $67–309

  3. Train (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    16h 15m
    $230–479

  4. Bus

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    16h 30m
    $120–210

  5. Drive 656.3 mi

    1. Drive from Harrisburg, Pa to Chicagocar car 656.3 mi
    10h 50m
    $120–173

  6. Train to Philadelphia International Airport, fly to Chicago Midway International Airport

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)plane plane PHL - MDW
    6h 5m
    $178–474

  7. Bus via Baltimore

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    21h 25m
    $122–253

Harrisburg, Pa to Chicago by train (Amtrak)

Calendar7Weekly Trains
Duration16h 15mAverage Duration
Ticket$230Cheapest Price
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Questions & Answers

Map of how to get from Harrisburg, Pa to Chicago.ExpandLaunch map view
  • Distance: 620.2 mi
  • Duration: 4h 21m

What companies run services between Harrisburg, Pa, PA, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, you can take a train from Harrisburg to Chicago Union Station via Pittsburgh Amtrak Station in around 16h 15m.

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