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How to get fromHarrisburg, Pa to Des Moinesby plane, train, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

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There are 8 ways to get from Harrisburg, Pa to Des Moines by plane, train, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Des Moines (DSM)plane plane MDT - DSM
    6h 6m
    $328–1,523

  2. Bus via Indianapolis (Greyhound)

    cheapest
    1. Take the bus from Harrisburg Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus Greyhound US0157S
    24h 15m
    $156–302

  3. Train, bus

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    23h 54m
    $279–581

  4. Bus

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    24h
    $178–311

  5. Drive 971.9 mi

    1. Drive from Harrisburg, Pa to Des Moinescar car 971.9 mi
    16h 3m
    $178–257

  6. Bus to Penn State University Park Airport, fly

    1. Take the bus from Harrisburg Bus Station to State College Regional Airportbus bus
    2. Fly from Penn State University Park Airport (SCE) to Des Moines (DSM)plane plane SCE - DSM
    7h 6m
    $172–746

  7. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Des Moines (DSM)plane plane PHL - DSM
    6h 22m
    $273–1,191

  8. Train, bus via Galesburg

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    25h 46m
    $309–651

Harrisburg, Pa to Des Moines by train, foot, and bus

Calendar7Weekly Services
Duration23h 54mAverage Duration
Ticket$279Cheapest Price
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Questions & Answers

Map of how to get from Harrisburg, Pa to Des Moines.ExpandLaunch map view
  • Distance: 901.9 mi
  • Duration: 6h 6m

What companies run services between Harrisburg, Pa, PA, USA and Des Moines, IA, USA?

United Airlines, Delta, and American Airlines fly from Harrisburg International Airport (MDT) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Harrisburg Bus Station to Des Moines via Chicago Bus Station in around 24h.

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