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How to get fromHarrisburg, Pa to Great Lakesby plane, train (Amtrak), bus (Flixbus), car, bus, or bus (Greyhound)

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There are 6 ways to get from Harrisburg, Pa to Great Lakes by plane, train (Amtrak), bus (Flixbus), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    4h 19m
    $113–657

  2. Bus to Penn State University Park Airport, fly

    cheapest
    1. Take the bus from Harrisburg Bus Station to State College Regional Airportbus bus
    2. Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane plane SCE - ORD
    5h 22m
    $67–319

  3. Train (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    16h 27m
    $231–483

  4. Bus (Flixbus)

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    16h 49m
    $127–208

  5. Drive 656.3 mi

    1. Drive from Harrisburg, Pa to Chicagocar car 656.3 mi
    10h 50m
    $120–173

  6. Bus via Baltimore (Greyhound)

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    21h 44m
    $125–245

Harrisburg, Pa to Great Lakes by train and bus (Amtrak)

Calendar7Weekly Services
Duration16h 27mAverage Duration
Ticket$231Cheapest Price
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Questions & Answers

Map of how to get from Harrisburg, Pa to Great Lakes.ExpandLaunch map view
  • Distance: 619.9 mi
  • Duration: 4h 19m

What companies run services between Harrisburg, Pa, PA, USA and Great Lakes, MI, USA?

American Airlines, United Airlines, and Delta fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, you can take a train from Harrisburg to Jackson & Wabash via Pittsburgh Amtrak Station, Chicago Union Station, and Jackson & Clinton in around 16h 27m.

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