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How to get fromHarrisburg, Pa to Iowaby plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

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There are 9 ways to get from Harrisburg, Pa to Iowa by plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Harrisburg International Airport to Quad City International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Quad City International Airport (MLI)plane plane MDT - MLI
    7h 21m
    $163–804

  2. Fly Harrisburg International Airport to Chicago O'Hare International Airport, bus

    cheapest
    1. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    2. Take the bus from Chicago to Davenportbus bus
    8h 38m
    $158–727

  3. Bus

    1. Take the bus from Harrisburg Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus Greyhound US0157S
    24h 10m
    $167–319

  4. Train, bus

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago to Des Moinesbus bus
    24h 34m
    $310–599

  5. Drive 971.9 mi

    1. Drive from Harrisburg, Pa to Des Moinescar car 971.9 mi
    16h 3m
    $178–257

  6. Train to Philadelphia International Airport, fly to Des Moines

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Des Moines (DSM)plane plane PHL - DSM
    6h 19m
    $273–1,190

  7. Fly Harrisburg International Airport to The Eastern Iowa Airport, bus

    1. Fly from Harrisburg International Airport (MDT) to The Eastern Iowa Airport (CID)plane plane MDT - CID
    2. Take the bus from GTC Bay 9 to Court St Transportation Centerbus bus
    8h 41m

  8. Bus via Chicago

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    2. Take the bus from Chicago to Des Moinesbus bus Btw 1205 / ...
    24h 40m
    $252–356

  9. Train, bus via Galesburg

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    25h 51m
    $318–665

Harrisburg, Pa to Iowa by train, foot, and bus

Calendar7Weekly Services
Duration24h 34mAverage Duration
Ticket$310Cheapest Price
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Questions & Answers

Map of how to get from Harrisburg, Pa to Iowa.ExpandLaunch map view
  • Distance: 742.6 mi
  • Duration: 7h 21m

What companies run services between Harrisburg, Pa, PA, USA and Iowa, USA?

United Airlines, Delta, and American Airlines fly from Harrisburg International Airport (MDT) to Quad City International Airport (MLI) every 2 hours. Alternatively, you can take a bus from Harrisburg Bus Station to Des Moines via Indianapolis Union Station and Des Moines in around 24h 10m.

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