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How to get fromHarrisburg, Pa to Knoxvilleby plane, train, bus, car, or bus (Flixbus)

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There are 6 ways to get from Harrisburg, Pa to Knoxville by plane, train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS)plane plane MDT - TYS
    5h 35m
    $286–1,372

  2. Drive 537 mi

    cheapest
    1. Drive from Harrisburg, Pa to Knoxvillecar car 537 mi
    9h
    $98–142

  3. Train, bus

    1. Take the train from Harrisburg to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    17h 6m
    $199–289

  4. Bus to Penn State University Park Airport, fly

    1. Take the bus from Harrisburg Bus Station to State College Regional Airportbus bus
    2. Fly from Penn State University Park Airport (SCE) to Mcghee Tyson Airport (TYS)plane plane SCE - TYS
    6h 56m
    $180–744

  5. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    5h 40m
    $250–1,040

  6. Bus

    1. Take the bus from Harrisburg Bus Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    21h 45m
    $134–173

Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) flights

Calendar99Weekly Planes
Duration4h 55mAverage Duration
Ticket$233Cheapest Price
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Questions & Answers

Map of how to get from Harrisburg, Pa to Knoxville.ExpandLaunch map view
  • Distance: 519 mi
  • Duration: 5h 35m

What companies run services between Harrisburg, Pa, PA, USA and Knoxville, TN, USA?

United Airlines, American Airlines, and two other airlines fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Harrisburg Bus Station to Knoxville Station Hall of Fame via New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 21h 45m.

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