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How to get fromHarrisburg, Pa to Louisvilleby plane, bus (Flixbus), car, train, or bus (Greyhound)

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There are 5 ways to get from Harrisburg, Pa to Louisville by plane, bus (Flixbus), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Louisville International Airport (SDF)plane plane MDT - SDF
    6h 29m
    $192–1,105

  2. Bus via Columbus

    cheapest
    1. Take the bus from Harrisburg Bus Station to Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus Cleveland
    14h 20m
    $78–168

  3. Bus

    1. Take the bus from Harrisburg Bus Station to Cincinnatibus bus FlixBus N2642
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus Cleveland
    14h 17m
    $92–183

  4. Drive 566.4 mi

    1. Drive from Harrisburg, Pa to Louisvillecar car 566.4 mi
    9h 50m
    $104–150

  5. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Louisville International Airport (SDF)plane plane PHL - SDF
    6h 52m
    $167–823

Harrisburg, Pa to Louisville by bus and foot

Calendar7Weekly Services
Duration14h 17mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

Map of how to get from Harrisburg, Pa to Louisville.ExpandLaunch map view
  • Distance: 516 mi
  • Duration: 6h 29m

What companies run services between Harrisburg, Pa, PA, USA and Louisville, KY, USA?

United Airlines, Delta, and American Airlines fly from Harrisburg International Airport (MDT) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Harrisburg Bus Station to Louisville, KY Bus Station via Cincinnati, Vine St & Martin Luther King Dr, Race St & Court St, and Cincinnati - Downtown in around 14h 17m.

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