Rome2Rio

How to get fromHartsville to Chicagoby bus, plane, bus (Greyhound, Flixbus), taxi, train, or car

Find Transport to Chicago

See all options

There are 10 ways to get from Hartsville to Chicago by bus, plane, bus (Greyhound, Flixbus), taxi, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Myrtle Beach, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    6h 49m
    $150–407

  2. Drive  821.3 mi

    cheapest
    1. Drive from Hartsville to Chicagocar car 821.3 mi
    14h 43m
    $141–203

  3. Bus

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S / ...
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    24h 7m
    $240–374

  4. Taxi, train (Amtrak)

    1. Take the taxi from Hartsville to Camden Stationtaxi taxi
    2. Take the train from Camden Station to Chicago Union Stationtrain train Floridian
    29h 33m
    $777–1,250

  5. Taxi, bus to Charlotte Douglas International Airport, fly to Chicago O'Hare International Airport

    1. Take the taxi from Hartsville to Camdentaxi taxi
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Chicago O'Hare International Airport (ORD)plane plane CLT - ORD
    7h 10m
    $189–473

  6. Taxi, bus to Charlotte Douglas International Airport, fly to Chicago Midway International Airport

    1. Take the taxi from Hartsville to Camdentaxi taxi
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Chicago Midway International Airport (MDW)plane plane CLT - MDW
    6h 52m
    $209–583

  7. Taxi, bus to Columbia, fly to Chicago O'Hare International Airport

    1. Take the taxi from Hartsville to Camdentaxi taxi
    2. Take the bus from Camden to Columbia, SCbus bus
    3. Fly from Columbia (CAE) to Chicago O'Hare International Airport (ORD)plane plane CAE - ORD
    7h 49m
    $208–489

  8. Train to Charleston International Airport, fly to Chicago Midway International Airport

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    7h 57m
    $222–658

  9. Taxi, bus to Charlotte Douglas International Airport, fly to South Bend, train

    1. Take the taxi from Hartsville to Camdentaxi taxi
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to South Bend (SBN)plane plane CLT - SBN
    4. Take the train from South Bend Airport to Van Buren St.train train
    8h 50m
    $216–565

  10. Bus to Raleigh-Durham International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Florence to Raleigh Bus Stationbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Chicago Midway International Airport (MDW)plane plane RDU - MDW
    8h 53m
    $168–549

Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD) flights

Calendar48Weekly Planes
Duration4h 30mAverage Duration
Ticket$52Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Hartsville to Chicago.ExpandLaunch map view
  • Distance: 865.3 mi
  • Duration: 6h 49m

What companies run services between Hartsville, SC, USA and Chicago, IL, USA?

You can take a vehicle from Hartsville to Chicago Bus Station via Florence Bus Station and Atlanta Bus Station in around 24h 7m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There