Rome2Rio

How to get fromHartsville to Jacksonvilleby bus (Flixbus), train (Amtrak), car, taxi, plane, bus (Greyhound), or bus

Find Transport to Jacksonville

See all options

There are 6 ways to get from Hartsville to Jacksonville by bus (Flixbus), train (Amtrak), car, taxi, plane, bus (Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Flixbus)

    best
    1. Take the bus from Florence to Jacksonvillebus bus FlixBus N2472
    6h 13m
    $113–164

  2. Drive 318.4 mi

    cheapest
    1. Drive from Hartsville to Jacksonvillecar car 318.4 mi
    5h 22m
    $59–84

  3. Train (Amtrak)

    1. Take the train from Florence Station to Jacksonvilletrain train Silver Meteor
    7h 31m
    $187–322

  4. Taxi to Florence Regional Airport, fly

    1. Take the taxi from Hartsville to Florence Regional Airport (FLO)taxi taxi
    2. Fly from Florence Regional Airport (FLO) to Jacksonville (JAX)plane plane FLO - JAX
    6h 24m
    $142–469

  5. Bus via Sumter (Greyhound)

    1. Take the bus from Florence Bus Station to Sumter Bus Stopbus bus Greyhound US0645S
    2. Take the bus from Sumter Bus Stop to Jacksonvillebus bus Greyhound US0644S
    8h 54m
    $126–196

  6. Taxi, bus to Charlotte Douglas International Airport, fly

    1. Take the taxi from Hartsville to Camdentaxi taxi
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Jacksonville (JAX)plane plane CLT - JAX
    7h 12m
    $206–612

Florence Regional Airport (FLO) to Jacksonville (JAX) flights

Calendar13Weekly Planes
Duration4h 32mAverage Duration
Ticket$64Cheapest Price
See schedules

Questions & Answers

Map of how to get from Hartsville to Jacksonville.ExpandLaunch map view
  • Distance: 335.3 mi
  • Duration: 6h 13m

What companies run services between Hartsville, SC, USA and Jacksonville, FL, USA?

Flixbus USA operates a bus from Florence to Jacksonville 5 times a week. Tickets cost $50–90 and the journey takes 5h 45m. Alternatively, Amtrak operates a train from Florence Station to Jacksonville once daily. Tickets cost $110–230 and the journey takes 6h 6m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers