There are 5 ways to get from Holguín to Cayo Santa María by bus, train, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Holguín to Santa Clarabus Holguin
- Take the bus from Santa Clara to Cayo Santa Maríabus Santa Clara
10h 30m$11–22Train, bus
- Take the train from Holguin to Santa Claratrain 16
- Take the bus from Santa Clara to Cayo Santa Maríabus Santa Clara
13h 54m$11–24Drive 469.9 km
- Drive from Holguín to Cayo Santa Maríacar 469.9 km
7h 15m$55–80Fly, bus
- Fly from Frank País International Airport (HOG) to Abel Santamaría Airport (SNU)plane HOG - SNU
- Take the bus from Santa Clara to Cayo Santa Maríabus
27h 50m$97–430Bus via Holguin
- Take the bus from Holguin to Santa Clarabus Santiago de Cuba parada en Guaimaro / ...
- Take the bus from Santa Clara to Cayo Santa Maríabus Santa Clara
12h 36m$41–62
Frank País International Airport (HOG) to Abel Santamaría Airport (SNU) flights
Comparing Your Travel Options
The cheapest way to get from Holguín to Cayo Santa María is to bus which costs $11 - $22 and takes 10h 30m.
The fastest way to get from Holguín to Cayo Santa María is to drive which takes 7h 15m and costs $55 - $80.
No, there is no direct bus from Holguín to Cayo Santa María. However, there are services departing from Holguín and arriving at Cayo Santa María via Parque and Santa Clara. The journey, including transfers, takes approximately 10h 30m.
The distance between Holguín and Cayo Santa María is 584 km. The road distance is 469.9 km.
The best way to get from Holguín to Cayo Santa María without a car is to bus which takes 10h 30m and costs $11 - $22.
It takes approximately 10h 30m to get from Holguín to Cayo Santa María, including transfers.
Holguín to Cayo Santa María bus services, operated by Ómnibus Nacionales, depart from Holguín station.
Holguín to Cayo Santa María bus services, operated by Ómnibus Nacionales, arrive at Santa Clara station.
Yes, the driving distance between Holguín to Cayo Santa María is 470 km. It takes approximately 7h 15m to drive from Holguín to Cayo Santa María.
What companies run services between Holguín, Cuba and Cayo Santa María, Villa Clara, Cuba?
You can take a bus from Holguín to Cayo Santa María via Parque, Vc, and Santa Clara in around 10h 30m.
- Website
- aa.com
Flights from Frank País International Airport to Abel Santamaría Airport via Miami
- Ave. Duration
- 23h 10m
- When
- Every day
- Estimated price
- $70–390
- Phone
- +53 7 855 5025 / 7 855 5026 / 5 2161205
- [email protected]
- Website
- facebook.com
Train from Holguin to Santa Clara
- Ave. Duration
- 10h 12m
- Frequency
- Twice a week
- Estimated price
- $3–8
- Schedules at
- Horario de Buses Cuba
- Normal
- $3
- Climatizado
- $5
- Phone
- +53 7873 7373
- [email protected]
- Website
- Ómnibus Nacionales
Bus from Holguín to Santa Clara
- Ave. Duration
- 7h
- Frequency
- 4 times a week
- Estimated price
- $3–6
- Schedules at
- Ómnibus Nacionales
- Phone
- +53 59 89 0616
- [email protected]
- Website
- Viazul
Bus from Santa Clara to Cayo Santa María
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $8–16
- Website
- Viazul
Bus from Santa Clara to Cayo Santa María
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $8–16
- Website
- Viazul
Bus from Santa Clara to Cayo Santa María
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $8–16
- Website
- Viazul
Bus from Holguin to Santa Clara
- Ave. Duration
- 9h 26m
- Frequency
- 4 times a day
- Estimated price
- $30–50
- Website
- Viazul
Bus from Santa Clara to Cayo Santa María
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $8–16
- Website
- Viazul
Want to know more about travelling around the world?
Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including How to get from Florence to Rome, Train travel in Spain: A guide to Renfe, and 4 of the smartest ways to explore Australia - to help you get the most out of your next trip.









