There are 7 ways to get from Holliston to Ithaca by bus (Greyhound, Flixbus), train, bus, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Framingham to Springfield Union Stationbus Greyhound US0270s
- Take the bus from Springfield Union Station to Ithacabus FlixBus 2691
9h 43m$60–92Drive 314 mi
cheapest- Drive from Holliston to Ithacacar 314 mi
5h 56m$58–83Train, bus
- Take the train from Framingham Amtrak to Utica Amtrak Stationtrain Lake Shore Limited
- Take the bus from Utica Bus Stop to Ithacabus FlixBus 2691
11h 48m$168–268Fly to Ithaca Tompkins Regional Airport
- Fly from Boston Logan Airport (BOS) to Ithaca Tompkins Regional Airport (ITH)plane BOS - ITH
8h 48m$74–400Fly to Rochester, bus
- Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane BOS - ROC
- Take the bus from Rochester to Ithacabus
8h 6m$162–850Train, fly to Syracuse Hancock International Airport, bus
- Take the train from Framingham to Back Baytrain
- Fly from Boston Logan Airport (BOS) to Syracuse Hancock International Airport (SYR)plane BOS - SYR
- Take the bus from Syracuse Bus Station to Ithacabus
8h 8m$126–812Fly to Buffalo Niagara International Airport, bus
- Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane BOS - BUF
- Take the bus from Buffalo Niagara International Airport to Ithacabus
9h 24m$128–660
Holliston to Ithaca by bus
Comparing Your Travel Options
The cheapest way to get from Holliston to Ithaca is to drive which costs $55 - $85 and takes 5h 56m.
The fastest way to get from Holliston to Ithaca is to drive which takes 5h 56m and costs $55 - $85.
No, there is no direct bus from Holliston to Ithaca. However, there are services departing from Downtown Holliston and arriving at Ithaca via Framingham and Springfield Union Station. The journey, including transfers, takes approximately 9h 43m.
The distance between Holliston and Ithaca is 374 miles. The road distance is 315.8 miles.
The best way to get from Holliston to Ithaca without a car is to bus which takes 9h 43m and costs $55 - $95.
It takes approximately 9h 43m to get from Holliston to Ithaca, including transfers.
Holliston to Ithaca bus services, operated by Greyhound USA, depart from Framingham station.
The best way to get from Holliston to Ithaca is to bus which takes 9h 43m and costs $55 - $95. Alternatively, you can fly, which costs $70 - $400 and takes 8h 48m.
Holliston to Ithaca bus services, operated by Greyhound USA, arrive at Springfield Union Station.
Yes, the driving distance between Holliston to Ithaca is 316 miles. It takes approximately 5h 56m to drive from Holliston to Ithaca.
What companies run services between Holliston, MA, USA and Ithaca, NY, USA?
You can take a bus from Downtown Holliston to Ithaca via Framingham MBTA Station, Framingham, and Springfield Union Station in around 9h 43m. Alternatively, United Airlines, Delta, and JetBlue Airways fly from Boston Logan Airport (BOS) to Ithaca Tompkins Regional Airport (ITH) every 4 hours.
- Website
- aa.com
Flights from Boston Logan Airport to Rochester
- Ave. Duration
- 1h 37m
- When
- Every day
- Estimated price
- $110–750
Flights from Boston Logan Airport to Rochester via Philadelphia
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $140–850
Flights from Boston Logan Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- $100–750
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $90–600
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 3h 54m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–600
- Website
- united.com
Flights from Boston Logan Airport to Ithaca Tompkins Regional Airport via Washington Dulles
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- $75–430
Flights from Boston Logan Airport to Rochester via Newark
- Ave. Duration
- 3h 57m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–800
Flights from Boston Logan Airport to Rochester via Washington Dulles
- Ave. Duration
- 4h 5m
- When
- Monday to Wednesday
- Estimated price
- $160–900
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Newark
- Ave. Duration
- 3h 55m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–600
- Website
- delta.com
Flights from Boston Logan Airport to Ithaca Tompkins Regional Airport via New York JFK
- Ave. Duration
- 5h 17m
- When
- Every day
- Estimated price
- $60–380
Flights from Boston Logan Airport to Rochester via New York La Guardia
- Ave. Duration
- 4h 1m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–800
- Website
- jetblue.com
Flights from Boston Logan Airport to Rochester via New York JFK
- Ave. Duration
- 3h 39m
- When
- Every day
- Estimated price
- $130–800
Flights from Boston Logan Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 19m
- When
- Every day
- Estimated price
- $100–750
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $90–600
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York JFK
- Ave. Duration
- 3h 38m
- When
- Friday
- Estimated price
- $100–600
- Website
- southwest.com
Flights from Boston Logan Airport to Rochester via Baltimore
- Ave. Duration
- 4h 1m
- When
- Tuesday, Wednesday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $160–900
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 3h 40m
- When
- Sunday
- Estimated price
- $110–650
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Framingham Amtrak to Utica Amtrak Station
- Ave. Duration
- 7h 20m
- Frequency
- Once daily
- Estimated price
- $150–240
- Website
- Amtrak
Train from Framingham to Back Bay
- Ave. Duration
- 50 min
- Frequency
- Hourly
- Estimated price
- $3–10
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $3–10
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Framingham to Springfield Union Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $13–20
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Springfield Union Station to Ithaca
- Ave. Duration
- 5h 44m
- Frequency
- 3 times a week
- Estimated price
- $45–70
- Schedules at
- Flixbus USA
Bus from Utica Bus Stop to Ithaca
- Ave. Duration
- 2h 9m
- Frequency
- 3 times a week
- Estimated price
- $17–27
- Schedules at
- Flixbus USA
Bus from Syracuse Bus Station to Ithaca
- Ave. Duration
- 1h 9m
- Frequency
- 3 times a week
- Estimated price
- $9–15
- Schedules at
- Flixbus USA
Bus from Buffalo Niagara International Airport to Ithaca
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- $24–40
- Schedules at
- Flixbus USA
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