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How to get fromHonolulu to Mayo Clinicby plane, bus, or car

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There are 3 ways to get from Honolulu to Mayo Clinic by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Daniel K. Inouye International Airport (HNL) to Rochester (RST)plane plane HNL - RST
    12h 57m
    $244–993

  2. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Daniel K. Inouye International Airport (HNL) to Minneapolis–Saint Paul International Airport (MSP)plane plane HNL - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    12h 16m
    $383–1,153

  3. Fly to Waterloo Municipal Airport, drive

    1. Fly from Daniel K. Inouye International Airport (HNL) to Waterloo Municipal Airport (ALO)plane plane HNL - ALO
    2. Drive from Waterloo Municipal Airport (ALO) to Mayo Cliniccar car
    18h 16m
    $293–1,033

Daniel K. Inouye International Airport (HNL) to Rochester (RST) flights

Calendar21Weekly Planes
Duration12h 50mAverage Duration
Ticket$249Cheapest Price
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Comparing Your Travel Options

Map of how to get from Honolulu to Mayo Clinic.ExpandLaunch map view
  • Distance: 4,016.5 mi
  • Duration: 12h 57m

What companies run services between Honolulu, HI, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Daniel K. Inouye International Airport (HNL) to Rochester (RST) 3 times a day.

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