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How to get fromHonolulu to Mayo Clinicby plane, bus, or car

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There are 3 ways to get from Honolulu to Mayo Clinic by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Daniel K. Inouye International Airport (HNL) to Rochester (RST)plane plane HNL - RST
    15h 56m
    $244–993

  2. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Daniel K. Inouye International Airport (HNL) to Minneapolis–Saint Paul International Airport (MSP)plane plane HNL - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    12h 4m
    $375–1,155

  3. Fly to Waterloo Municipal Airport, drive

    1. Fly from Daniel K. Inouye International Airport (HNL) to Waterloo Municipal Airport (ALO)plane plane HNL - ALO
    2. Drive from Waterloo Municipal Airport (ALO) to Mayo Cliniccar car
    18h 1m
    $283–1,033

Daniel K. Inouye International Airport (HNL) to Rochester (RST) flights

Calendar30Weekly Planes
Duration14h 9mAverage Duration
Ticket$239Cheapest Price
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Comparing Your Travel Options

Map of how to get from Honolulu to Mayo Clinic.ExpandLaunch map view
  • Distance: 4,016.5 mi
  • Duration: 15h 56m

What companies run services between Honolulu, HI, USA and Mayo Clinic, MN, USA?

American Airlines, Delta, and United Airlines fly from Daniel K. Inouye International Airport (HNL) to Rochester (RST) 4 times a day.

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Bus operators

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