Rome2Rio

How to get fromHouston to Mayo Clinicby plane, bus (Flixbus, Greyhound), bus, train, or car

Find Transport to Mayo Clinic

See all options

There are 8 ways to get from Houston to Mayo Clinic by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly George Bush Intercontinental Airport to Rochester

    best
    1. Fly from George Bush Intercontinental Airport (IAH) to Rochester (RST)plane plane IAH - RST
    8h
    $104–534

  2. Bus

    1. Take the bus from Downtown Houston to Oklahoma City Bus Stationbus bus
    2. Take the bus from Oklahoma City Bus Station to Tulsa Bus Stationbus bus
    3. Take the bus from Tulsa to St. Paulbus bus
    4. Take the bus from St. Paul to Rochesterbus bus
    30h 33m
    $275–404

  3. Bus, train

    1. Take the bus from Houston to Longviewbus bus
    2. Take the train from Longview to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    34h 52m

  4. Drive  1,125.6 mi

    1. Drive from Houston to Mayo Cliniccar car 1,125.6 mi
    18h 42m
    $206–297

  5. Fly William P. Hobby Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from William P. Hobby Airport (HOU) to Minneapolis–Saint Paul International Airport (MSP)plane plane HOU - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 22m
    $161–651

  6. Fly George Bush Intercontinental Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from George Bush Intercontinental Airport (IAH) to Minneapolis–Saint Paul International Airport (MSP)plane plane IAH - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 52m
    $173–654

  7. Bus via Milwaukee

    1. Take the bus from Houston, TX - 808 Jefferson St to Dallas, TX - 1376 Marilla Stbus bus
    2. Take the bus from Dallas to Water & Chicago - Circle Kbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    32h 52m
    $355–421

  8. Train, bus

    1. Take the train from Houston to New Orleans Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    41h 4m
    $948–1,497

Houston to Mayo Clinic by bus and foot

Calendar6Weekly Services
Duration30h 33mAverage Duration
Ticket$275Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Houston to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,008.3 mi
  • Duration: 8h

What companies run services between Houston, TX, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from George Bush Intercontinental Airport (IAH) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Downtown Houston to Mayo Clinic via Oklahoma City Bus Station, Tulsa, St. Paul, and Rochester in around 30h 33m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There