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How to get fromHouston to Mayo Clinicby plane, bus (Flixbus, Greyhound), bus, train, or car

Find Transport to Mayo Clinic

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There are 8 ways to get from Houston to Mayo Clinic by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly George Bush Intercontinental Airport to Rochester

    best
    1. Fly from George Bush Intercontinental Airport (IAH) to Rochester (RST)plane plane IAH - RST
    7h 53m
    $104–544

  2. Bus

    1. Take the bus from Downtown Houston to Dallas Bus Stationbus bus
    2. Take the bus from Dallas Bus Station to Tulsa Bus Stationbus bus
    3. Take the bus from Tulsa to Owatonnabus bus
    4. Take the bus from Owatonna to Rochesterbus bus
    27h 23m
    $222–364

  3. Bus, train

    1. Take the bus from Houston to Longviewbus bus
    2. Take the train from Longview to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    34h 52m
    $347–697

  4. Drive  1,125.6 mi

    1. Drive from Houston to Mayo Cliniccar car 1,125.6 mi
    18h 42m
    $206–297

  5. Fly George Bush Intercontinental Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from George Bush Intercontinental Airport (IAH) to Minneapolis–Saint Paul International Airport (MSP)plane plane IAH - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 32m
    $175–656

  6. Fly William P. Hobby Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from William P. Hobby Airport (HOU) to Minneapolis–Saint Paul International Airport (MSP)plane plane HOU - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 3m
    $203–803

  7. Fly William P. Hobby Airport to Rochester

    1. Fly from William P. Hobby Airport (HOU) to Rochester (RST)plane plane HOU - RST
    9h 32m
    $132–691

  8. Bus via Milwaukee

    1. Take the bus from Houston, TX - 808 Jefferson St to Dallas, TX - 1376 Marilla Stbus bus
    2. Take the bus from Dallas to Water & Chicago - Circle Kbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    32h 52m
    $356–422

Houston to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration27h 23mAverage Duration
Ticket$222Cheapest Price
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Comparing Your Travel Options

Map of how to get from Houston to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,008.3 mi
  • Duration: 7h 53m

What companies run services between Houston, TX, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from George Bush Intercontinental Airport (IAH) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Downtown Houston to Mayo Clinic via Dallas Bus Station, Tulsa, Owatonna, and Rochester in around 27h 23m.

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