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How to get fromHouston to Mayo Clinicby plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Flixbus)

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There are 8 ways to get from Houston to Mayo Clinic by plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly George Bush Intercontinental Airport to Rochester

    best
    1. Fly from George Bush Intercontinental Airport (IAH) to Rochester (RST)plane plane IAH - RST
    7h 51m
    $114–594

  2. Bus via Kansas City

    1. Take the bus from Downtown Houston to Dallas Bus Stationbus bus
    2. Take the bus from Dallas Bus Station to Kansas City Bus Stationbus bus
    3. Take the bus from Kansas City Bus Station to Saint Paul Union Depotbus bus
    4. Take the bus from St. Paul to Rochester, MNbus bus
    30h 8m
    $223–415

  3. Bus, train

    1. Take the bus from Houston to Longviewbus bus
    2. Take the train from Longview to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    35h 12m
    $427–830

  4. Drive 1,125.6 mi

    1. Drive from Houston to Mayo Cliniccar car 1,125.6 mi
    18h 42m
    $206–297

  5. Fly William P. Hobby Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from William P. Hobby Airport (HOU) to Minneapolis–Saint Paul International Airport (MSP)plane plane HOU - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 2m
    $243–953

  6. Fly George Bush Intercontinental Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from George Bush Intercontinental Airport (IAH) to Minneapolis–Saint Paul International Airport (MSP)plane plane IAH - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 32m
    $185–706

  7. Bus

    1. Take the bus from Downtown Houston to Downtown Dallas / Deep Ellumbus bus
    2. Take the bus from Dallas to Water & Chicago - Circle Kbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    33h
    $271–475

  8. Train, bus

    1. Take the train from Houston to New Orleans Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    41h 9m
    $577–1,199

Houston to Mayo Clinic by bus and foot

Calendar5Weekly Services
Duration30h 8mAverage Duration
Ticket$223Cheapest Price
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Questions & Answers

Map of how to get from Houston to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,008.3 mi
  • Duration: 7h 51m

What companies run services between Houston, TX, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from George Bush Intercontinental Airport (IAH) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Downtown Houston to Mayo Clinic via Dallas Bus Station, Kansas City Bus Station, Saint Paul Union Depot, St. Paul, and Rochester in around 30h 8m.

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