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How to get fromHyannis to Charlestonby plane, train (Amtrak), car, bus, or train

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There are 5 ways to get from Hyannis to Charleston by plane, train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Charleston International Airport (CHS)plane plane HYA - CHS
    6h 2m
    $109–512

  2. Train

    1. Take the train from Hyannis to South Stationtrain train
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Charleston Amtrak Stationtrain train
    22h 46m
    $315–1,292

  3. Drive 969.6 mi

    1. Drive from Hyannis to Charlestoncar car 969.6 mi
    18h 28m
    $177–256

  4. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Charleston International Airport (CHS)plane plane BOS - CHS
    7h 19m
    $630–988

  5. Bus, train

    1. Take the bus from Hyannis Transportation Center to South Station Transp. Ctrbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Charleston Amtrak Stationtrain train
    23h 45m
    $291–579

Hyannis to Charleston by bus and train

Calendar14Weekly Services
Duration23h 45mAverage Duration
Ticket$291Cheapest Price
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Questions & Answers

Map of how to get from Hyannis to Charleston.ExpandLaunch map view
  • Distance: 822.8 mi
  • Duration: 6h 2m

What companies run services between Hyannis, MA, USA and Charleston, SC, USA?

Cape Air, JetBlue Airways, and two other airlines fly from Barnstable Municipal Airport (HYA) to Charleston International Airport (CHS) 4 times a day. Alternatively, you can take a train from Hyannis to Charleston via South Station, Boston, Ny Moynihan Train Hall At Penn Station, and Charleston Amtrak Station in around 22h 46m.

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