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How to get fromHyannis to Columbiaby plane, bus, train, bus (Flixbus), car, or bus (Greyhound)

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There are 6 ways to get from Hyannis to Columbia by plane, bus, train, bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Columbia (CAE)plane plane HYA - CAE
    6h 20m
    $239–1,143

  2. Bus

    cheapest
    1. Take the bus from Hyannis Transportation Center to South Station Transp. Ctrbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York, NY to Columbia, SCbus bus Nyc
    23h 53m
    $159–237

  3. Bus, train

    1. Take the bus from Hyannis Transportation Center to South Station Transp. Ctrbus bus
    2. Take the train from Boston to Washington Union Stationtrain train
    3. Take the train from Washington Union Station to Columbia Stationtrain train
    21h 19m
    $327–675

  4. Drive 947.2 mi

    1. Drive from Hyannis to Columbiacar car 947.2 mi
    17h 9m
    $173–250

  5. Bus, train via New York

    1. Take the bus from Hyannis Transportation Center to South Station Transp. Ctrbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Washington Union Stationtrain train
    4. Take the train from Washington Union Station to Columbia Stationtrain train
    21h 30m
    $307–1,275

  6. Bus via Charlotte

    1. Take the bus from Hyannis to Providencebus bus
    2. Take the bus from Peter Pan Bus Terminal to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Sumter Bus Stopbus bus
    5. Take the bus from James E Clyburn Intermodal Transportation Center to Assembly Gervais Northbus bus 44
    27h 42m
    $168–380

Hyannis to Columbia by bus and train

Calendar7Weekly Services
Duration21h 19mAverage Duration
Ticket$327Cheapest Price
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Questions & Answers

Map of how to get from Hyannis to Columbia.ExpandLaunch map view
  • Distance: 804.4 mi
  • Duration: 6h 20m

What companies run services between Hyannis, MA, USA and Columbia, SC, USA?

American Airlines flies from Barnstable Municipal Airport (HYA) to Columbia (CAE) twice daily. Alternatively, you can take a bus from Hyannis Transportation Center to Sumter Laurel South via South Station Transp. Ctr, Boston, NYC Downtown, New York, NY, Columbia, SC, and Broad Marley South in around 23h 53m.

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