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How to get fromHyannis to Frederickby plane, bus, train, bus (Flixbus), car, or bus (Greyhound)

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There are 8 ways to get from Hyannis to Frederick by plane, bus, train, bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Barnstable Municipal Airport to Ronald Reagan Washington National Airport, bus

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Ronald Reagan Washington National Airport (DCA)plane plane HYA - DCA
    2. Take the bus from SHADY GROVE & station to Frederick Marc Stationbus bus
    4h 34m
    $111–656

  2. Drive  476.1 mi

    cheapest
    1. Drive from Hyannis to Frederickcar car 476.1 mi
    9h 17m
    $87–126

  3. Bus, train via Hanover

    1. Take the bus from Hyannis to Bostonbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to BWI Thurgood Marshalltrain train
    4. Take the bus from BWI Amtrak Station to Frederick Transit Centerbus bus Bwi
    11h 53m

  4. Bus via Boston

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Baltimore Downtown Bus Stationbus bus
    4. Take the bus from Baltimore to Frederickbus bus
    13h 13m
    $157–255

  5. Bus to Boston Logan Airport, fly to Baltimore-Washington International Airport, bus

    1. Take the bus from Hyannis to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Baltimore-Washington International Airport (BWI)plane plane BOS - BWI
    3. Take the bus from Baltimore to Frederickbus bus
    6h 32m
    $235–1,086

  6. Bus, train

    1. Take the bus from Hyannis to Bostonbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Washington Union Stationtrain train
    4. Take the train from Washington Union Station to FREDERICK MARC wbtrain train
    12h 18m
    $186–976

  7. Bus, train #2

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Washington Union Stationtrain train
    3. Take the train from Washington Union Station to FREDERICK MARC wbtrain train
    12h 23m
    $279–437

  8. Bus

    1. Take the bus from Hyannis to Providencebus bus
    2. Take the bus from Providence to New Yorkbus bus
    3. Take the bus from New York to Baltimorebus bus
    4. Take the bus from Baltimore to Frederickbus bus
    13h 35m
    $104–191

Hyannis to Frederick by bus

Calendar13Weekly Buses
Duration13h 13mAverage Duration
Ticket$157Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hyannis to Frederick.ExpandLaunch map view
  • Distance: 457.3 mi
  • Duration: 4h 34m

What companies run services between Hyannis, MA, USA and Frederick, MD, USA?

You can take a bus from Hyannis Transportation Center to Frederick via Boston, South Station, Boston, New York Midtown, and Baltimore in around 13h 13m.

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