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How to get fromHyannis to Key Westby plane, bus (Flixbus, Greyhound), bus, train, or car

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There are 5 ways to get from Hyannis to Key West by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Key West International Airport (EYW)plane plane HYA - EYW
    19h 58m
    $116–470

  2. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    42h 11m
    $261–454

  3. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    43h 8m
    $485–1,698

  4. Drive 1,677.2 mi

    1. Drive from Hyannis to Key Westcar car 1,677.2 mi
    29h 52m
    $307–443

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Key West International Airport (EYW)plane plane BOS - EYW
    6h 51m
    $123–466

Hyannis to Key West by bus and foot

Calendar4Weekly Services
Duration42h 11mAverage Duration
Ticket$261Cheapest Price
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Questions & Answers

Map of how to get from Hyannis to Key West.ExpandLaunch map view
  • Distance: 1,355 mi
  • Duration: 19h 58m

What companies run services between Hyannis, MA, USA and Key West, FL, USA?

Cape Air, JetBlue Airways, and American Airlines fly from Barnstable Municipal Airport (HYA) to Key West International Airport (EYW) 3 times a week. Alternatively, you can take a bus from Hyannis Transportation Center to N Roosevelt & 3rd Street via Boston, South Station, Boston, Washington Union Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 42h 11m.

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