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How to get fromHyannis to Knoxvilleby plane, bus, train, car, bus (Greyhound), or bus (Flixbus)

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There are 6 ways to get from Hyannis to Knoxville by plane, bus, train, car, bus (Greyhound), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Mcghee Tyson Airport (TYS)plane plane HYA - TYS
    4h 51m
    $331–1,472

  2. Drive  945.6 mi

    cheapest
    1. Drive from Hyannis to Knoxvillecar car 945.6 mi
    16h 57m
    $162–234

  3. Bus, train

    1. Take the bus from Hyannis to Bostonbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    19h 56m
    $202–937

  4. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Mcghee Tyson Airport (TYS)plane plane BOS - TYS
    5h 35m
    $310–1,396

  5. Bus via New York

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    20h 42m
    $250–348

  6. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    20h 55m
    $237–335

Barnstable Municipal Airport (HYA) to Mcghee Tyson Airport (TYS) flights

Calendar18Weekly Planes
Duration6h 47mAverage Duration
Ticket$275Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hyannis to Knoxville.ExpandLaunch map view
  • Distance: 853.7 mi
  • Duration: 4h 51m

What companies run services between Hyannis, MA, USA and Knoxville, TN, USA?

American Airlines, Cape Air, and two other airlines fly from Barnstable Municipal Airport (HYA) to Mcghee Tyson Airport (TYS) 3 times a day. Alternatively, you can take a bus from Hyannis Transportation Center to Knoxville via Boston, South Station, Boston, Port Authority Bus Terminal, 42 St-Bryant Park, East Broadway, New York, and Knoxville in around 20h 42m.

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