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How to get fromHyannis to Knoxvilleby bus, plane, train, car, bus (Flixbus), or bus (Greyhound)

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There are 8 ways to get from Hyannis to Knoxville by bus, plane, train, car, bus (Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Mcghee Tyson Airport (TYS)plane plane BOS - TYS
    5h 58m
    $253–1,056

  2. Bus to Boston Logan Airport, fly to Asheville Regional Airport, drive

    cheapest
    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Asheville Regional Airport (AVL)plane plane BOS - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 47m
    $130–501

  3. Bus, train via Farragut

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    20h 7m
    $260–1,038

  4. Drive  945.6 mi

    1. Drive from Hyannis to Knoxvillecar car 945.6 mi
    16h 57m
    $173–250

  5. Fly Barnstable Municipal Airport to Mcghee Tyson Airport

    1. Fly from Barnstable Municipal Airport (HYA) to Mcghee Tyson Airport (TYS)plane plane HYA - TYS
    5h 58m
    $259–1,082

  6. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    20h 11m
    $215–948

  7. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    20h 56m
    $237–335

  8. Bus via New York

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    21h 10m
    $240–353

Boston Logan Airport (BOS) to Mcghee Tyson Airport (TYS) flights

Calendar69Weekly Planes
Duration4h 32mAverage Duration
Ticket$179Cheapest Price
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Questions & Answers

Map of how to get from Hyannis to Knoxville.ExpandLaunch map view
  • Distance: 918.5 mi
  • Duration: 5h 58m

What companies run services between Hyannis, MA, USA and Knoxville, TN, USA?

Cape Air and Allegiant Air fly from Barnstable Municipal Airport (HYA) to Mcghee Tyson Airport (TYS) 6 times a week. Alternatively, you can take a bus from Hyannis Transportation Center to Knoxville via Boston, South Station, Boston, NYC Downtown, New York, and Knoxville in around 20h 56m.

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