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How to get fromHyannis to Knoxvilleby plane, bus, train, car, or bus (Flixbus)

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There are 7 ways to get from Hyannis to Knoxville by plane, bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Mcghee Tyson Airport (TYS)plane plane HYA - TYS
    5h 41m
    $237–937

  2. Drive 945.6 mi

    cheapest
    1. Drive from Hyannis to Knoxvillecar car 945.6 mi
    16h 56m
    $173–250

  3. Bus, train via Farragut

    1. Take the bus from Hyannis Transportation Center to South Station Transp. Ctrbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    20h 7m
    $260–1,041

  4. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Mcghee Tyson Airport (TYS)plane plane BOS - TYS
    6h 1m
    $233–856

  5. Bus, train

    1. Take the bus from Hyannis Transportation Center to South Station Transp. Ctrbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    20h 11m
    $215–951

  6. Bus

    1. Take the bus from Hyannis to Providencebus bus
    2. Take the bus from Peter Pan Bus Terminal to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    20h 33m
    $233–397

  7. Bus via Boston

    1. Take the bus from Hyannis Transportation Center to South Station Transp. Ctrbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    20h 55m
    $262–368

Barnstable Municipal Airport (HYA) to Mcghee Tyson Airport (TYS) flights

Calendar11Weekly Planes
Duration6h 33mAverage Duration
Ticket$181Cheapest Price
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Questions & Answers

Map of how to get from Hyannis to Knoxville.ExpandLaunch map view
  • Distance: 853.7 mi
  • Duration: 5h 41m

What companies run services between Hyannis, MA, USA and Knoxville, TN, USA?

American Airlines, Cape Air, and two other airlines fly from Barnstable Municipal Airport (HYA) to Mcghee Tyson Airport (TYS) twice daily. Alternatively, you can take a bus from Hyannis to Knoxville via Peter Pan Bus Terminal, Port Authority Bus Terminal, 42 St-Bryant Park, East Broadway, New York, and Knoxville in around 20h 33m.

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