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How to get fromHyannis to Louisvilleby plane, bus (Greyhound), bus, train, car, or bus (Flixbus)

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There are 7 ways to get from Hyannis to Louisville by plane, bus (Greyhound), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Louisville International Airport (SDF)plane plane HYA - SDF
    5h 30m
    $142–675

  2. Bus via Brook Park

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Wilson & Ferrell Shell Station - Columbusbus bus
    4. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Louisville, KY Bus Stationbus bus
    25h 35m
    $169–340

  3. Bus, train via Toledo

    1. Take the bus from Hyannis Transportation Center to Boston South Stationbus bus
    2. Take the train from Boston to Toledotrain train
    3. Take the bus from Toledo to Indianapolis, INbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    28h 33m
    $309–698

  4. Drive 972.8 mi

    1. Drive from Hyannis to Louisvillecar car 972.8 mi
    17h 51m
    $178–257

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Louisville International Airport (SDF)plane plane BOS - SDF
    7h 3m
    $149–639

  6. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Cincinnatibus bus
    4. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    27h 20m
    $177–338

  7. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    34h 14m
    $409–1,480

Hyannis to Louisville by bus

Calendar7Weekly Buses
Duration25h 35mAverage Duration
Ticket$169Cheapest Price
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Questions & Answers

Map of how to get from Hyannis to Louisville.ExpandLaunch map view
  • Distance: 858.2 mi
  • Duration: 5h 30m

What companies run services between Hyannis, MA, USA and Louisville, KY, USA?

American Airlines, Cape Air, and Delta fly from Barnstable Municipal Airport (HYA) to Louisville International Airport (SDF) twice daily. Alternatively, you can take a bus from Hyannis Transportation Center to Louisville, KY Bus Station via Boston, Bus Terminal South Station, Boston, Cleveland Bus Station, and N Wilson Rd & Ferrell Pl - Columbus in around 25h 35m.

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