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How to get fromHyannis to Louisvilleby bus, plane, bus (Greyhound), train, car, or bus (Flixbus)

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There are 9 ways to get from Hyannis to Louisville by bus, plane, bus (Greyhound), train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly to Louisville International Airport

    best
    1. Take the bus from Hyannis to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Louisville International Airport (SDF)plane plane BOS - SDF
    6h 35m
    $146–685

  2. Bus, train to Theodore Francis Green State Airport, fly to Louisville International Airport

    cheapest
    1. Take the bus from Hyannis to Bostonbus bus
    2. Take the train from South Station to TF Green Airporttrain train
    3. Fly from Theodore Francis Green State Airport (PVD) to Louisville International Airport (SDF)plane plane PVD - SDF
    10h 39m
    $144–700

  3. Bus via Brook Park

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Wilson & Ferrell Shell Station - Columbusbus bus
    4. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Louisville, KY Bus Stationbus bus
    25h 35m
    $161–325

  4. Bus, train via Toledo

    1. Take the bus from Hyannis to Bostonbus bus
    2. Take the train from Boston to Toledotrain train
    3. Take the bus from Toledo to Indianapolis, INbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    28h 27m
    $277–621

  5. Drive 972.8 mi

    1. Drive from Hyannis to Louisvillecar car 972.8 mi
    17h 52m
    $178–257

  6. Fly Barnstable Municipal Airport to Louisville International Airport

    1. Fly from Barnstable Municipal Airport (HYA) to Louisville International Airport (SDF)plane plane HYA - SDF
    6h 21m
    $148–716

  7. Bus to Boston Logan Airport, fly to Covington, bus

    1. Take the bus from Hyannis to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Covington (CVG)plane plane BOS - CVG
    3. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    9h 4m
    $446–1,079

  8. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Cincinnatibus bus
    4. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    27h 19m
    $166–303

  9. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    34h 14m
    $359–1,430

Hyannis to Louisville by bus

Calendar7Weekly Buses
Duration25h 35mAverage Duration
Ticket$161Cheapest Price
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Questions & Answers

Map of how to get from Hyannis to Louisville.ExpandLaunch map view
  • Distance: 907.9 mi
  • Duration: 6h 35m

What companies run services between Hyannis, MA, USA and Louisville, KY, USA?

You can take a bus from Hyannis Transportation Center to Louisville, KY Bus Station via Boston, South Station, Boston, Cleveland Bus Station, and N Wilson Rd & Ferrell Pl - Columbus in around 25h 35m. Alternatively, Cape Air, Delta, and American Airlines fly from Barnstable Municipal Airport (HYA) to Louisville International Airport (SDF) 3 times a day.

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