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How to get fromHyannis to Louisvilleby bus, plane, train, bus (Greyhound), car, or bus (Flixbus)

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There are 9 ways to get from Hyannis to Louisville by bus, plane, train, bus (Greyhound), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly to Louisville International Airport

    best
    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Louisville International Airport (SDF)plane plane BOS - SDF
    7h 2m
    $169–789

  2. Fly Barnstable Municipal Airport to Louisville International Airport

    cheapest
    1. Fly from Barnstable Municipal Airport (HYA) to Louisville International Airport (SDF)plane plane HYA - SDF
    6h 18m
    $166–823

  3. Bus, train via Toledo

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Toledotrain train
    3. Take the bus from Toledo Bus Stop to Louisville Bus Stationbus bus
    27h 3m
    $272–570

  4. Bus via Brook Park

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Louisville Bus Stationbus bus
    27h 5m
    $182–300

  5. Drive  972.8 mi

    1. Drive from Hyannis to Louisvillecar car 972.8 mi
    17h 52m
    $178–257

  6. Bus to Boston Logan Airport, fly to Covington, bus

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Covington (CVG)plane plane BOS - CVG
    3. Take the bus from Cincinnati to Louisvillebus bus
    9h 28m
    $459–1,083

  7. Bus, train to Theodore Francis Green State Airport, fly to Louisville International Airport

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from South Station to TF Green Airporttrain train
    3. Fly from Theodore Francis Green State Airport (PVD) to Louisville International Airport (SDF)plane plane PVD - SDF
    10h 39m
    $167–754

  8. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Cincinnatibus bus
    4. Take the bus from Cincinnati to Louisvillebus bus
    27h 19m
    $177–313

  9. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    33h 39m
    $339–1,380

Hyannis to Louisville by bus and train

Calendar7Weekly Services
Duration27h 3mAverage Duration
Ticket$272Cheapest Price
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Questions & Answers

Map of how to get from Hyannis to Louisville.ExpandLaunch map view
  • Distance: 909.7 mi
  • Duration: 7h 2m

What companies run services between Hyannis, MA, USA and Louisville, KY, USA?

You can take a bus from Hyannis Transportation Center to Louisville Bus Station via Boston, South Station, Boston, and Cleveland Bus Station in around 27h 5m. Alternatively, Cape Air, Delta, and American Airlines fly from Barnstable Municipal Airport (HYA) to Louisville International Airport (SDF) 4 times a day.

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