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How to get fromHyannis to Louisvilleby plane, bus, train, bus (Greyhound, Amtrak), car, or bus (Flixbus, Amtrak)

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There are 7 ways to get from Hyannis to Louisville by plane, bus, train, bus (Greyhound, Amtrak), car, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Louisville International Airport (SDF)plane plane HYA - SDF
    6h 33m
    $168–850

  2. Bus, train via Toledo

    1. Take the bus from Hyannis to Bostonbus bus
    2. Take the train from Boston to Toledotrain train
    3. Take the bus from Toledo to Indianapolisbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    27h 57m
    $487–834

  3. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to New Yorkbus bus
    3. Take the bus from Port Authority Bus Terminal to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    28h 22m
    $229–365

  4. Drive  972.8 mi

    1. Drive from Hyannis to Louisvillecar car 972.8 mi
    17h 51m
    $178–257

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Hyannis to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Louisville International Airport (SDF)plane plane BOS - SDF
    6h 40m
    $176–879

  6. Bus via Reading

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Cincinnatibus bus
    4. Take the bus from Cincinnati to Indianapolisbus bus
    5. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    32h 1m
    $213–390

  7. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    33h 44m
    $599–1,630

Hyannis to Louisville by bus, foot, and train

Calendar7Weekly Services
Duration27h 57mAverage Duration
Ticket$487Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hyannis to Louisville.ExpandLaunch map view
  • Distance: 858.2 mi
  • Duration: 6h 33m

What companies run services between Hyannis, MA, USA and Louisville, KY, USA?

American Airlines, Cape Air, and Delta fly from Barnstable Municipal Airport (HYA) to Louisville International Airport (SDF) 4 times a day. Alternatively, you can take a bus from Hyannis Transportation Center to Louisville, KY via Boston, South Station, Boston, New York, Port Authority Bus Terminal, and Indianapolis Union Station in around 28h 22m.

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