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How to get fromHyannis to San Diegoby plane, bus, train, bus (Greyhound, Amtrak), or car

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There are 6 ways to get from Hyannis to San Diego by plane, bus, train, bus (Greyhound, Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Barnstable Municipal Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to San Diego International Airport (SAN)plane plane HYA - SAN
    8h 51m
    $220–900

  2. Bus to Boston Logan Airport, fly

    cheapest
    1. Take the bus from Hyannis to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to San Diego International Airport (SAN)plane plane BOS - SAN
    9h 5m
    $155–426

  3. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    4. Take the train from Fullerton Amtrak Station to San Diegotrain train
    3d
    $1,832–2,925

  4. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to New Yorkbus bus
    3. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    5. Take the bus from Los Angeles to San Diegobus bus
    3d 4h

  5. Drive  2,983.8 mi

    1. Drive from Hyannis to San Diegocar car 2,983.8 mi
    2d 2h
    $528–762

  6. Bus, train via New York

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    4. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    5. Take the train from Fullerton Amtrak Station to San Diegotrain train
    3d 3h
    $1,472–2,315

Hyannis to San Diego by bus and train

Calendar7Weekly Services
Duration3dAverage Duration
Ticket$1,832Cheapest Price
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Comparing Your Travel Options

Map of how to get from Hyannis to San Diego.ExpandLaunch map view
  • Distance: 2,620.8 mi
  • Duration: 8h 51m

What companies run services between Hyannis, MA, USA and San Diego, CA, USA?

American Airlines, Cape Air, and JetBlue Airways fly from Barnstable Municipal Airport (HYA) to San Diego International Airport (SAN) 3 times a day. Alternatively, you can take a bus from Hyannis Transportation Center to San Diego via Boston, South Station, Boston, New York, Port Authority Bus Terminal, St Louis Bus Station, Los Angeles Union Station, and Los Angeles in around 3d 4h.

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