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How to get fromHyannis to South Carolinaby plane, train (Amtrak), car, bus, or taxi

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There are 5 ways to get from Hyannis to South Carolina by plane, train (Amtrak), car, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Barnstable Municipal Airport to Charleston International Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Charleston International Airport (CHS)plane plane HYA - CHS
    5h 31m
    $109–512

  2. Train

    1. Take the train from Hyannis to South Stationtrain train
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Charleston Amtrak Stationtrain train
    22h 46m
    $315–1,292

  3. Drive 969.6 mi

    1. Drive from Hyannis to Charlestoncar car 969.6 mi
    18h 28m
    $177–256

  4. Bus to Boston Logan Airport, fly to Charlotte Douglas International Airport, taxi

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Charlotte Douglas International Airport (CLT)plane plane BOS - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    6h 12m
    $258–436

  5. Bus to Boston Logan Airport, fly to Charleston International Airport

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Charleston International Airport (CHS)plane plane BOS - CHS
    6h 48m
    $630–988

Barnstable Municipal Airport (HYA) to Charleston International Airport (CHS) flights

Calendar31Weekly Planes
Duration5h 26mAverage Duration
Ticket$106Cheapest Price
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Questions & Answers

Map of how to get from Hyannis to South Carolina.ExpandLaunch map view
  • Distance: 815.9 mi
  • Duration: 5h 31m

What companies run services between Hyannis, MA, USA and South Carolina, USA?

Cape Air, JetBlue Airways, and two other airlines fly from Barnstable Municipal Airport (HYA) to Charleston International Airport (CHS) 4 times a day. Alternatively, you can take a train from Hyannis to Charleston via South Station, Boston, Ny Moynihan Train Hall At Penn Station, and Charleston Amtrak Station in around 22h 46m.

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